WNT activates the AAK1 kinase to promote clathrin-mediated endocytosis of LRP6 and establish a negative feedback loop

WNT activates the AAK1 kinase to promote clathrin-mediated endocytosis of LRP6 and establish a negative feedback loop

β-Catenin-dependent WNT signal transduction governs development, tissue homeostasis, and a vast array of human diseases. Signal propagation through a WNT-Frizzled/LRP receptor complex requires proteins necessary for clathrin-mediated endocytosis (CME). Paradoxically, CME also negatively regulates WN...

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Bibliographic Details
Main Authors: Agajanian, M, Walker, M, Axtman, A, Ruela-De-Sousa, R, Serafin, D, Rabinowitz, A, Graham, D, Ryan, M, Tamir, T, Nakamichi, Y, Gammons, M, Bennett, J, Couñago, R, Drewry, D, Elkins, J, Gileadi, C, Gileadi, O, Godoi, P, Kapadia, N, Müller, S, Santiago, A, Sorrell, F, Wells, C, Fedorov, O, Willson, T, Zuercher, W, Major, M
Format: Journal article
Language:English
Published: Elsevier 2019

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