The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases.
Mutations in isocitrate dehydrogenases (IDHs) have a gain-of-function effect leading to R(-)-2-hydroxyglutarate (R-2HG) accumulation. By using biochemical, structural and cellular assays, we show that either or both R- and S-2HG inhibit 2-oxoglutarate (2OG)-dependent oxygenases with varying potencie...
Main Authors: | Chowdhury, R, Yeoh, K, Tian, Y, Hillringhaus, L, Bagg, E, Rose, N, Leung, I, Li, X, Woon, E, Yang, M, McDonough, M, King, O, Clifton, I, Klose, R, Claridge, T, Ratcliffe, P, Schofield, C, Kawamura, A |
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Format: | Journal article |
Language: | English |
Published: |
2011
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