Overexpression of sarcoendoplasmic reticulum calcium ATPase 2a promotes cardiac sympathetic neurotransmission via abnormal endoplasmic reticulum and mitochondria Ca(2+) regulation.
<p>Reduced cardiomyocyte excitation–contraction coupling and downregulation of the SERCA2a (sarcoendoplasmic reticulum calcium ATPase 2a) is associated with heart failure. This has led to viral transgene upregulation of SERCA2a in cardiomyocytes as a treatment. We hypothesized that SERCA2a gen...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
American Heart Association
2017
|