Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors.

Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors.

Tumour necrosis factor-alpha (TNF) expression is increased in inflammatory bowel disease (IBD), and TNF maps to the IBD3 susceptibility locus. Transmission disequilibrium and case-control analyses, in two independent Caucasian cohorts, showed a novel association of the TNF(-857C) promoter polymorphi...

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Bibliographic Details
Main Authors:	van Heel, D, Udalova, I, De Silva, A, McGovern, D, Kinouchi, Y, Hull, J, Lench, N, Cardon, L, Carey, A, Jewell, D, Kwiatkowski, D
Format:	Journal article
Language:	English
Published:	2002

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