Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors.

Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors.

Tumour necrosis factor-alpha (TNF) expression is increased in inflammatory bowel disease (IBD), and TNF maps to the IBD3 susceptibility locus. Transmission disequilibrium and case-control analyses, in two independent Caucasian cohorts, showed a novel association of the TNF(-857C) promoter polymorphi...

ver descrição completa

Detalhes bibliográficos
Main Authors:	van Heel, D, Udalova, I, De Silva, A, McGovern, D, Kinouchi, Y, Hull, J, Lench, N, Cardon, L, Carey, A, Jewell, D, Kwiatkowski, D
Formato:	Journal article
Idioma:	English
Publicado em:	2002

Registos relacionados

Inflammatory bowel disease is associated with functional TNF polymorphism affecting OCT1/NF-kappa B interaction
Por: van Heel, D, et al.
Publicado em: (2002)

Inflammatory bowel disease is associated with a functional TNF polymorphism that affects an OCT1/NF-KB transcription factor interaction
Por: Van Heel, D, et al.
Publicado em: (2002)

Association of accelerated erosive rheumatoid arthritis with a polymorphism that alters NF-kappaB binding to the TNF promoter region.
Por: Udalova, I, et al.
Publicado em: (2002)

Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region.
Por: Udalova, I, et al.
Publicado em: (2001)

Functional consequences of a polymorphism affecting NF-kappaB p50-p50 binding to the TNF promoter region.
Por: Udalova, I, et al.
Publicado em: (2000)

Association between a complex insertion/deletion polymorphism in NOD1 (CARD4) and susceptibility to inflammatory bowel disease.
Por: McGovern, D, et al.
Publicado em: (2005)

Identification of novel polymorphisms in the beta7 integrin gene: family-based association studies in inflammatory bowel disease.
Por: van Heel, D, et al.
Publicado em: (2001)

Quantitative prediction of NF-kappa B DNA-protein interactions.
Por: Udalova, I, et al.
Publicado em: (2002)

Analysis of the IBD5 locus and potential gene-gene interactions in Crohn's disease.
Por: Negoro, K, et al.
Publicado em: (2003)

A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria.
Por: Knight, J, et al.
Publicado em: (1999)

Fine mapping of the IBD1 locus did not identify Crohn disease-associated NOD2 variants: implications for complex disease genetics.
Por: van Heel, D, et al.
Publicado em: (2002)

TUCAN (CARD8) genetic variants and inflammatory bowel disease.
Por: McGovern, D, et al.
Publicado em: (2006)

Inflammatory bowel disease: progress toward a gene.
Por: van Heel, D, et al.
Publicado em: (2000)

Genetics of inflammatory bowel disease--an update.
Por: van Heel, D, et al.
Publicado em: (2001)

The efficacy of methotrexate for maintaining remission in inflammatory bowel disease.
Por: Fraser, A, et al.
Publicado em: (2002)

Direct evidence for involvement of NF-kappaB in transcriptional activation of tumor necrosis factor by a spirochetal lipoprotein.
Por: Udalova, I, et al.
Publicado em: (2000)

Activation of nuclear factor-kappa B (NF-kappa B)in diarrhoea predominant irritable bowel syndrome
Por: O'Sullivan, M, et al.
Publicado em: (2001)

Complex NF-kappaB interactions at the distal tumor necrosis factor promoter region in human monocytes.
Por: Udalova, I, et al.
Publicado em: (1998)

Rac mediates TNF-induced cytokine production via modulation of NF-kappaB.
Por: Williams, L, et al.
Publicado em: (2008)

Comparing the fine specificity of DNA binding by NF-kappaB p50 and p52 using principal coordinates analysis.
Por: Nijnik, A, et al.
Publicado em: (2003)

Genetics of inflammatory bowel disease: a reappraisal.
Por: Orchard, T, et al.
Publicado em: (2000)

Are cytokine gene polymorphisms important in the pathogenesis of inflammatory bowel disease?
Por: Satsangi, J, et al.
Publicado em: (1996)

The IBD6 Crohn's disease locus demonstrates complex interactions with CARD15 and IBD5 disease-associated variants.
Por: van Heel, D, et al.
Publicado em: (2003)

Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies.
Por: Koss, K, et al.
Publicado em: (2000)

NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.
Por: Smith, C, et al.
Publicado em: (2001)

Detecting and modulating the NF-kB activity in human immune cells: generation of human cell lines with altered levels of NF-kappaB.
Por: Goh, F, et al.
Publicado em: (2009)

Crohn's disease: genetic susceptibility, bacteria, and innate immunity.
Por: Van Heel, D, et al.
Publicado em: (2001)

Mechanism of inactivation of NF-kappa B by a viral homologue of I kappa b alpha. Signal-induced release of i kappa b alpha results in binding of the viral homologue to NF-kappa B.
Por: Tait, S, et al.
Publicado em: (2000)

Salicylates for inflammatory bowel disease.
Por: Travis, S, et al.
Publicado em: (1994)

Evolution of a polymorphic regulatory element in interferon-gamma through transposition and mutation.
Por: Ackerman, H, et al.
Publicado em: (2002)

NOD2 (CARD15), the first susceptibility gene for Crohn's disease.
Por: McGovern, D, et al.
Publicado em: (2001)

Immunology of inflammatory bowel disease--an update.
Por: Jewell, D
Publicado em: (1995)

DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene.
Por: Nedospasov, SA, et al.
Publicado em: (1991)

Immunology of inflammatory bowel disease.
Por: Jewell, D, et al.
Publicado em: (1985)

Immunology of inflammatory bowel disease.
Por: Hodgson, H, et al.
Publicado em: (1987)

The immunology of inflammatory bowel disease.
Por: Lowes, JR, et al.
Publicado em: (1990)

Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant.
Por: Andreakos, E, et al.
Publicado em: (2006)

Visualization of lymphatic vessels through NF-kappaB activity.
Por: Saban, MR, et al.
Publicado em: (2004)

Atopy in inflammatory bowel disease.
Por: Mee, A, et al.
Publicado em: (1979)

Conserved kappa B element located downstream of the tumor necrosis factor alpha gene: distinct NF-kappa B binding pattern and enhancer activity in LPS activated murine macrophages.
Por: Kuprash, D, et al.
Publicado em: (1995)