Intracranial pressure in African children with cerebral malaria.
Opening lumbar cerebrospinal fluid (CSF) pressure was measured with a paediatric spinal fluid manometer in 26 of 61 Kenyan children (mean age 39 months) with cerebral malaria. In all cases pressure was above normal (mean [SD]22.6 [7.4] cm CSF, range 10.5-36). Clinical features of our patients sugges...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1991
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| _version_ | 1826274751241256960 |
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| author | Newton, C Kirkham, F Winstanley, P Pasvol, G Peshu, N Warrell, D Marsh, K |
| author_facet | Newton, C Kirkham, F Winstanley, P Pasvol, G Peshu, N Warrell, D Marsh, K |
| author_sort | Newton, C |
| collection | OXFORD |
| description | Opening lumbar cerebrospinal fluid (CSF) pressure was measured with a paediatric spinal fluid manometer in 26 of 61 Kenyan children (mean age 39 months) with cerebral malaria. In all cases pressure was above normal (mean [SD]22.6 [7.4] cm CSF, range 10.5-36). Clinical features of our patients suggest that intracranial hypertension is important in the pathogenesis of cerebral malaria in children, especially as a cause of death. We suggest that raised intracranial pressure is secondary to increased cerebral blood volume. Lowering intracranial pressure may significantly reduce the mortality and morbidity of cerebral malaria. The potential risks and benefits of lumbar puncture should be considered carefully in patients with suspected cerebral malaria. |
| first_indexed | 2024-03-06T22:48:12Z |
| format | Journal article |
| id | oxford-uuid:5deaca75-c623-43d1-b350-5cefd5696457 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:48:12Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:5deaca75-c623-43d1-b350-5cefd56964572022-03-26T17:37:13ZIntracranial pressure in African children with cerebral malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5deaca75-c623-43d1-b350-5cefd5696457EnglishSymplectic Elements at Oxford1991Newton, CKirkham, FWinstanley, PPasvol, GPeshu, NWarrell, DMarsh, KOpening lumbar cerebrospinal fluid (CSF) pressure was measured with a paediatric spinal fluid manometer in 26 of 61 Kenyan children (mean age 39 months) with cerebral malaria. In all cases pressure was above normal (mean [SD]22.6 [7.4] cm CSF, range 10.5-36). Clinical features of our patients suggest that intracranial hypertension is important in the pathogenesis of cerebral malaria in children, especially as a cause of death. We suggest that raised intracranial pressure is secondary to increased cerebral blood volume. Lowering intracranial pressure may significantly reduce the mortality and morbidity of cerebral malaria. The potential risks and benefits of lumbar puncture should be considered carefully in patients with suspected cerebral malaria. |
| spellingShingle | Newton, C Kirkham, F Winstanley, P Pasvol, G Peshu, N Warrell, D Marsh, K Intracranial pressure in African children with cerebral malaria. |
| title | Intracranial pressure in African children with cerebral malaria. |
| title_full | Intracranial pressure in African children with cerebral malaria. |
| title_fullStr | Intracranial pressure in African children with cerebral malaria. |
| title_full_unstemmed | Intracranial pressure in African children with cerebral malaria. |
| title_short | Intracranial pressure in African children with cerebral malaria. |
| title_sort | intracranial pressure in african children with cerebral malaria |
| work_keys_str_mv | AT newtonc intracranialpressureinafricanchildrenwithcerebralmalaria AT kirkhamf intracranialpressureinafricanchildrenwithcerebralmalaria AT winstanleyp intracranialpressureinafricanchildrenwithcerebralmalaria AT pasvolg intracranialpressureinafricanchildrenwithcerebralmalaria AT peshun intracranialpressureinafricanchildrenwithcerebralmalaria AT warrelld intracranialpressureinafricanchildrenwithcerebralmalaria AT marshk intracranialpressureinafricanchildrenwithcerebralmalaria |