Extracellular microRNAs exhibit sequence-dependent stability and cellular release kinetics
Multiple studies have described extracellular microRNAs (ex-miRNAs) as being remarkably stable despite the hostile extracellular environment, when stored at 4ºC or lower. Here we show that many ex-miRNAs are rapidly degraded when incubated at 37ºC in the presence of serum (thereby simulating physiol...
Main Authors: | Coenen-Stass, A, Pauwels, M, Hanson, B, Martin Perez, C, Conceição, M, Wood, M, Mäger, I, Roberts, T |
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Format: | Journal article |
Language: | English |
Published: |
Taylor and Francis
2019
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