Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife
Short-term memory in middle-aged individuals with different APOE alleles was examined using a recently developed task which is sensitive to medial temporal lobe damage. Individuals (age-range: 40-51 years) with ε3/ε3, ε3/ε4 and ε4/ε4 APOE genotypes (N=60) performed a delayed estimation task with a s...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Published: |
Elsevier
2016
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| _version_ | 1797071158705651712 |
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| author | Zokaei, N Giehl, K Sillence, A Neville, M Karpe, F de Ozorio Nobre, A Husain, M |
| author_facet | Zokaei, N Giehl, K Sillence, A Neville, M Karpe, F de Ozorio Nobre, A Husain, M |
| author_sort | Zokaei, N |
| collection | OXFORD |
| description | Short-term memory in middle-aged individuals with different APOE alleles was examined using a recently developed task which is sensitive to medial temporal lobe damage. Individuals (age-range: 40-51 years) with ε3/ε3, ε3/ε4 and ε4/ε4 APOE genotypes (N=60) performed a delayed estimation task with a sensitive continuous measure of report. The paradigm allowed us to measure memory for items and their locations, as well as maintenance of identity-location feature binding in memory. There was a significant gene-dosage dependent effect of the ε4 allele on performance: memory decay or forgetting was slower in ε4 carriers, as measured by localization error and after controlling for misbinding errors. Furthermore ε4 carriers made less misbinding errors. These findings were specific to male carriers only. Thus, male ε4 carriers are at a behavioral advantage in midlife on a sensitive task of short-term memory. The results would be consistent with an antagonistic pleiotropy hypothesis and highlight the interaction of gender on the influence of APOE in cognition. |
| first_indexed | 2024-03-06T22:49:15Z |
| format | Journal article |
| id | oxford-uuid:5e427f03-407e-4bd5-b480-77c5523f0a56 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:49:15Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:5e427f03-407e-4bd5-b480-77c5523f0a562022-03-26T17:39:28ZSex and APOE: A memory advantage in male APOE ε4 carriers in midlifeJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5e427f03-407e-4bd5-b480-77c5523f0a56Symplectic Elements at OxfordElsevier2016Zokaei, NGiehl, KSillence, ANeville, MKarpe, Fde Ozorio Nobre, AHusain, MShort-term memory in middle-aged individuals with different APOE alleles was examined using a recently developed task which is sensitive to medial temporal lobe damage. Individuals (age-range: 40-51 years) with ε3/ε3, ε3/ε4 and ε4/ε4 APOE genotypes (N=60) performed a delayed estimation task with a sensitive continuous measure of report. The paradigm allowed us to measure memory for items and their locations, as well as maintenance of identity-location feature binding in memory. There was a significant gene-dosage dependent effect of the ε4 allele on performance: memory decay or forgetting was slower in ε4 carriers, as measured by localization error and after controlling for misbinding errors. Furthermore ε4 carriers made less misbinding errors. These findings were specific to male carriers only. Thus, male ε4 carriers are at a behavioral advantage in midlife on a sensitive task of short-term memory. The results would be consistent with an antagonistic pleiotropy hypothesis and highlight the interaction of gender on the influence of APOE in cognition. |
| spellingShingle | Zokaei, N Giehl, K Sillence, A Neville, M Karpe, F de Ozorio Nobre, A Husain, M Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife |
| title | Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife |
| title_full | Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife |
| title_fullStr | Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife |
| title_full_unstemmed | Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife |
| title_short | Sex and APOE: A memory advantage in male APOE ε4 carriers in midlife |
| title_sort | sex and apoe a memory advantage in male apoe ε4 carriers in midlife |
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