Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin

Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin

The mechanisms by which truncating mutations in MYBPC3 (encoding cardiac myosin-binding protein C; cMyBPC) or myosin missense mutations cause hypercontractility and poor relaxation in hypertrophic cardiomyopathy (HCM) are incompletely understood. Using genetic and biochemical approaches, we explored...

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Bibliographic Details
Main Authors:	Toepfer, C, Wakimoto, H, Garfinkel, A, McDonough, B, Liao, D, Jiang, J, Tai, A, Gorham, J, Lunde, I, Lun, M, Lynch, T, McNamara, J, Sadayappan, S, Redwood, C, Watkins, H, Seidman, J, Seidman, C
Format:	Journal article
Language:	English
Published:	American Association for the Advancement of Science 2019

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