Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.

Pre-clinical evaluation of three non-viral gene transfer agents for cystic fibrosis after aerosol delivery to the ovine lung.

We use both large and small animal models in our pre-clinical evaluation of gene transfer agents (GTAs) for cystic fibrosis (CF) gene therapy. Here, we report the use of a large animal model to assess three non-viral GTAs: 25 kDa-branched polyethyleneimine (PEI), the cationic liposome (GL67A) and co...

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Main Authors: McLachlan, G, Davidson, H, Holder, E, Davies, L, Pringle, I, Sumner-Jones, S, Baker, A, Tennant, P, Gordon, C, Vrettou, C, Blundell, R, Hyndman, L, Stevenson, B, Wilson, A, Doherty, A, Shaw, D, Coles, R, Painter, H, Cheng, S, Scheule, R, Davies, J, Innes, J, Hyde, S, Griesenbach, U, Alton, E
Format: Journal article
Language:English
Published: 2011

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