3D fractional moving blood volume (3D-FMBV) demonstrates decreased first trimester placental vascularity in pre-eclampsia but not the term, small for gestation age baby.
<h4>Objectives</h4> <p>To undertake an observational study to see whether first trimester placental vascularity, measured with a standardized power Doppler index: 3D-FMBV, is different in pregnancies which either develop pre-eclampsia or lead to term, normotensive small for gestat...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal article |
| Language: | English |
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Public Library of Science
2017
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| _version_ | 1826274851968516096 |
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| author | Collins, S Welsh, A Impey, L Noble, J Stevenson, G |
| author2 | Gebhardt, S |
| author_facet | Gebhardt, S Collins, S Welsh, A Impey, L Noble, J Stevenson, G |
| author_sort | Collins, S |
| collection | OXFORD |
| description | <h4>Objectives</h4> <p>To undertake an observational study to see whether first trimester placental vascularity, measured with a standardized power Doppler index: 3D-FMBV, is different in pregnancies which either develop pre-eclampsia or lead to term, normotensive small for gestational age (SGA) babies.</p> <h4>Methods</h4> <p>Women were scanned between 11 and 13+6 weeks. The placental volume (sPlaV) was estimated using our previously validated semi-automated tool. Estimates of 3D-FMBV were generated from the raw power Doppler signal for the whole utero-placental interface, UPI (FMBV-UPI) and 5mm into the placenta (FMBV-IVS). Differences in the placental volume and FMBV for pregnancies developing pre-eclampsia and resulting in term, normotensive SGA babies were compared with term, normotensive, appropriate for gestational age (AGA), controls.</p> <h4>Results</h4> <p>Results were available for 143 women. The placental volume (sPlaV) was reduced in both pre-eclampsia (p = 0.007) and term, normotensive SGA (p = 0.001) when compared with term normotensive AGA controls. 3D-FMBV estimates were significantly lower for pregnancies developing pre-eclampsia (FMBV-UPI, p = 0.03, FMBV-IVS, p = 0.01) but not for the normotensive SGA pregnancies (FMBV-UPI, p = 0.16, FMBV-IVS, p = 0.27).</p> <h4>Conclusion</h4> <p>Pregnancies destined to develop pre-eclampsia are more likely to have small placentas with significantly reduced vascularity at 11±13 weeks. Those pregnancies which were normotensive throughout but resulted in an SGA baby delivered at term, had significantly smaller placentas but with similar vascularity to normotensive AGA pregnancies.</p> |
| first_indexed | 2024-03-06T22:49:45Z |
| format | Journal article |
| id | oxford-uuid:5e62f84f-acc5-4383-a192-231b44c9a793 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:49:45Z |
| publishDate | 2017 |
| publisher | Public Library of Science |
| record_format | dspace |
| spelling | oxford-uuid:5e62f84f-acc5-4383-a192-231b44c9a7932022-03-26T17:40:25Z3D fractional moving blood volume (3D-FMBV) demonstrates decreased first trimester placental vascularity in pre-eclampsia but not the term, small for gestation age baby.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5e62f84f-acc5-4383-a192-231b44c9a793EnglishSymplectic Elements at OxfordPublic Library of Science2017Collins, SWelsh, AImpey, LNoble, JStevenson, GGebhardt, S <h4>Objectives</h4> <p>To undertake an observational study to see whether first trimester placental vascularity, measured with a standardized power Doppler index: 3D-FMBV, is different in pregnancies which either develop pre-eclampsia or lead to term, normotensive small for gestational age (SGA) babies.</p> <h4>Methods</h4> <p>Women were scanned between 11 and 13+6 weeks. The placental volume (sPlaV) was estimated using our previously validated semi-automated tool. Estimates of 3D-FMBV were generated from the raw power Doppler signal for the whole utero-placental interface, UPI (FMBV-UPI) and 5mm into the placenta (FMBV-IVS). Differences in the placental volume and FMBV for pregnancies developing pre-eclampsia and resulting in term, normotensive SGA babies were compared with term, normotensive, appropriate for gestational age (AGA), controls.</p> <h4>Results</h4> <p>Results were available for 143 women. The placental volume (sPlaV) was reduced in both pre-eclampsia (p = 0.007) and term, normotensive SGA (p = 0.001) when compared with term normotensive AGA controls. 3D-FMBV estimates were significantly lower for pregnancies developing pre-eclampsia (FMBV-UPI, p = 0.03, FMBV-IVS, p = 0.01) but not for the normotensive SGA pregnancies (FMBV-UPI, p = 0.16, FMBV-IVS, p = 0.27).</p> <h4>Conclusion</h4> <p>Pregnancies destined to develop pre-eclampsia are more likely to have small placentas with significantly reduced vascularity at 11±13 weeks. Those pregnancies which were normotensive throughout but resulted in an SGA baby delivered at term, had significantly smaller placentas but with similar vascularity to normotensive AGA pregnancies.</p> |
| spellingShingle | Collins, S Welsh, A Impey, L Noble, J Stevenson, G 3D fractional moving blood volume (3D-FMBV) demonstrates decreased first trimester placental vascularity in pre-eclampsia but not the term, small for gestation age baby. |
| title | 3D fractional moving blood volume (3D-FMBV) demonstrates decreased first trimester placental vascularity in pre-eclampsia but not the term, small for gestation age baby. |
| title_full | 3D fractional moving blood volume (3D-FMBV) demonstrates decreased first trimester placental vascularity in pre-eclampsia but not the term, small for gestation age baby. |
| title_fullStr | 3D fractional moving blood volume (3D-FMBV) demonstrates decreased first trimester placental vascularity in pre-eclampsia but not the term, small for gestation age baby. |
| title_full_unstemmed | 3D fractional moving blood volume (3D-FMBV) demonstrates decreased first trimester placental vascularity in pre-eclampsia but not the term, small for gestation age baby. |
| title_short | 3D fractional moving blood volume (3D-FMBV) demonstrates decreased first trimester placental vascularity in pre-eclampsia but not the term, small for gestation age baby. |
| title_sort | 3d fractional moving blood volume 3d fmbv demonstrates decreased first trimester placental vascularity in pre eclampsia but not the term small for gestation age baby |
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