The presence of outer arm fucose residues on the N-glycans of tissue inhibitor of metalloproteinases-1 reduces its activity.

The presence of outer arm fucose residues on the N-glycans of tissue inhibitor of metalloproteinases-1 reduces its activity.

Tissue inhibitor of metalloproteinases-1 (TIMP-1) inhibits matrix metalloproteinases (MMPs) by binding at a 1:1 stoichiometry. Here we have shown the involvement of N-glycosylation in the MMP inhibitory ability of TIMP-1. TIMP-1, purified from HEK 293 cells overexpressing TIMP-1 (293 TIMP-1), showed...

Полное описание

Библиографические подробности
Главные авторы:	Kim, H, Saldova, R, Park, J, Lee, Y, Harvey, D, Wormald, M, Wynne, K, Elia, G, Rudd, P, Lee, S
Формат:	Journal article
Язык:	English
Опубликовано:	2013

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