Linking structural change with functional regulation-insights from mass spectrometry.
A wide range of biophysical approaches has been applied to structural biology, all with the same overall goal-to understand the molecular machines that allow cells to function. While knowledge of the identity and composition of component protein subunits is an important foundation for understanding...
| Autors principals: | , |
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| Format: | Journal article |
| Idioma: | English |
| Publicat: |
2012
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| _version_ | 1826274864142483456 |
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| author | Morgner, N Robinson, C |
| author_facet | Morgner, N Robinson, C |
| author_sort | Morgner, N |
| collection | OXFORD |
| description | A wide range of biophysical approaches has been applied to structural biology, all with the same overall goal-to understand the molecular machines that allow cells to function. While knowledge of the identity and composition of component protein subunits is an important foundation for understanding these macromolecular complexes it has become increasingly clear that knowledge of the exact composition alone is insufficient for understanding dynamic interactions and regulatory mechanisms. In this review we focus on recent developments of mass spectrometry (MS) that allow us to unravel the functional 'secrets' of non-covalent molecular machines. |
| first_indexed | 2024-03-06T22:49:57Z |
| format | Journal article |
| id | oxford-uuid:5e6ea840-41d5-44c8-9f07-be4fbc03f5d2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:49:57Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:5e6ea840-41d5-44c8-9f07-be4fbc03f5d22022-03-26T17:40:46ZLinking structural change with functional regulation-insights from mass spectrometry.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5e6ea840-41d5-44c8-9f07-be4fbc03f5d2EnglishSymplectic Elements at Oxford2012Morgner, NRobinson, CA wide range of biophysical approaches has been applied to structural biology, all with the same overall goal-to understand the molecular machines that allow cells to function. While knowledge of the identity and composition of component protein subunits is an important foundation for understanding these macromolecular complexes it has become increasingly clear that knowledge of the exact composition alone is insufficient for understanding dynamic interactions and regulatory mechanisms. In this review we focus on recent developments of mass spectrometry (MS) that allow us to unravel the functional 'secrets' of non-covalent molecular machines. |
| spellingShingle | Morgner, N Robinson, C Linking structural change with functional regulation-insights from mass spectrometry. |
| title | Linking structural change with functional regulation-insights from mass spectrometry. |
| title_full | Linking structural change with functional regulation-insights from mass spectrometry. |
| title_fullStr | Linking structural change with functional regulation-insights from mass spectrometry. |
| title_full_unstemmed | Linking structural change with functional regulation-insights from mass spectrometry. |
| title_short | Linking structural change with functional regulation-insights from mass spectrometry. |
| title_sort | linking structural change with functional regulation insights from mass spectrometry |
| work_keys_str_mv | AT morgnern linkingstructuralchangewithfunctionalregulationinsightsfrommassspectrometry AT robinsonc linkingstructuralchangewithfunctionalregulationinsightsfrommassspectrometry |