Identification of a yeast artificial chromosome that spans the human papillary renal cell carcinoma-associated t(X;1) breakpoint in Xp11.2.
Recently, a specific chromosome abnormality, t(X;1)(p11;q21), was described for a subgroup of human papillary renal cell carcinomas. The translocation breakpoint in Xp11 is located in the same region as that in t(X;18)(p11;q11)-positive synovial sarcoma. We used fluorescence in situ hybridization (F...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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1993
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| _version_ | 1826274880379682816 |
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| author | Suijkerbuijk, R Meloni, A Sinke, R de Leeuw, B Wilbrink, M Janssen, H Geraghty, M Monaco, A Sandberg, A Geurts van Kessel, A |
| author_facet | Suijkerbuijk, R Meloni, A Sinke, R de Leeuw, B Wilbrink, M Janssen, H Geraghty, M Monaco, A Sandberg, A Geurts van Kessel, A |
| author_sort | Suijkerbuijk, R |
| collection | OXFORD |
| description | Recently, a specific chromosome abnormality, t(X;1)(p11;q21), was described for a subgroup of human papillary renal cell carcinomas. The translocation breakpoint in Xp11 is located in the same region as that in t(X;18)(p11;q11)-positive synovial sarcoma. We used fluorescence in situ hybridization (FISH) and somatic cell hybridization techniques to demonstrate 1) that the Xp11 translocation breakpoint in papillary renal cell carcinoma differs from that observed in synovial sarcoma and has a more proximal location, and 2) that an ornithine aminotransferase (OAT)L2 containing yeast artificial chromosome (YAC) spans the X;1 translocation. This YAC provides an ideal starting point from which the breakpoint itself and the gene(s) involved can be isolated and characterized. |
| first_indexed | 2024-03-06T22:50:12Z |
| format | Journal article |
| id | oxford-uuid:5e848741-e953-4f19-9a08-92c4dc790e21 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:50:12Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:5e848741-e953-4f19-9a08-92c4dc790e212022-03-26T17:41:15ZIdentification of a yeast artificial chromosome that spans the human papillary renal cell carcinoma-associated t(X;1) breakpoint in Xp11.2.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5e848741-e953-4f19-9a08-92c4dc790e21EnglishSymplectic Elements at Oxford1993Suijkerbuijk, RMeloni, ASinke, Rde Leeuw, BWilbrink, MJanssen, HGeraghty, MMonaco, ASandberg, AGeurts van Kessel, ARecently, a specific chromosome abnormality, t(X;1)(p11;q21), was described for a subgroup of human papillary renal cell carcinomas. The translocation breakpoint in Xp11 is located in the same region as that in t(X;18)(p11;q11)-positive synovial sarcoma. We used fluorescence in situ hybridization (FISH) and somatic cell hybridization techniques to demonstrate 1) that the Xp11 translocation breakpoint in papillary renal cell carcinoma differs from that observed in synovial sarcoma and has a more proximal location, and 2) that an ornithine aminotransferase (OAT)L2 containing yeast artificial chromosome (YAC) spans the X;1 translocation. This YAC provides an ideal starting point from which the breakpoint itself and the gene(s) involved can be isolated and characterized. |
| spellingShingle | Suijkerbuijk, R Meloni, A Sinke, R de Leeuw, B Wilbrink, M Janssen, H Geraghty, M Monaco, A Sandberg, A Geurts van Kessel, A Identification of a yeast artificial chromosome that spans the human papillary renal cell carcinoma-associated t(X;1) breakpoint in Xp11.2. |
| title | Identification of a yeast artificial chromosome that spans the human papillary renal cell carcinoma-associated t(X;1) breakpoint in Xp11.2. |
| title_full | Identification of a yeast artificial chromosome that spans the human papillary renal cell carcinoma-associated t(X;1) breakpoint in Xp11.2. |
| title_fullStr | Identification of a yeast artificial chromosome that spans the human papillary renal cell carcinoma-associated t(X;1) breakpoint in Xp11.2. |
| title_full_unstemmed | Identification of a yeast artificial chromosome that spans the human papillary renal cell carcinoma-associated t(X;1) breakpoint in Xp11.2. |
| title_short | Identification of a yeast artificial chromosome that spans the human papillary renal cell carcinoma-associated t(X;1) breakpoint in Xp11.2. |
| title_sort | identification of a yeast artificial chromosome that spans the human papillary renal cell carcinoma associated t x 1 breakpoint in xp11 2 |
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