The NK-3 tachykinin agonist senktide elicits yawning and chewing mouth movements following subcutaneous administration in the rat. Evidence for cholinergic mediation.
The selective NK-3 tachykinin receptor agonist senktide elicited yawning, chewing mouth movements and sexual arousal following subcutaneous administration (0.1-1.0 mg/kg) in the rat. These responses were not significantly affected by the dopamine antagonist haloperidol (0.03 mg/kg) or by 6-hydroxydo...
| Главные авторы: | , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
1988
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| _version_ | 1826274882733735936 |
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| author | Stoessl, A Dourish, C Iversen, S |
| author_facet | Stoessl, A Dourish, C Iversen, S |
| author_sort | Stoessl, A |
| collection | OXFORD |
| description | The selective NK-3 tachykinin receptor agonist senktide elicited yawning, chewing mouth movements and sexual arousal following subcutaneous administration (0.1-1.0 mg/kg) in the rat. These responses were not significantly affected by the dopamine antagonist haloperidol (0.03 mg/kg) or by 6-hydroxydopamine lesions of the nigrostriatal projection. In contrast, the behaviours were markedly attenuated by the peripheral and central muscarinic antagonist scopolamine (1 mg/kg), but not by the peripheral muscarinic antagonist N-methylscopolamine (1 mg/kg). These findings suggest that stimulation of NK-3 receptors produces yawning, chewing and sexual arousal by directly activating central cholinergic neurons. |
| first_indexed | 2024-03-06T22:50:14Z |
| format | Journal article |
| id | oxford-uuid:5e88d964-017c-4d33-9de1-e8dc2ad1ad66 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:50:14Z |
| publishDate | 1988 |
| record_format | dspace |
| spelling | oxford-uuid:5e88d964-017c-4d33-9de1-e8dc2ad1ad662022-03-26T17:41:19ZThe NK-3 tachykinin agonist senktide elicits yawning and chewing mouth movements following subcutaneous administration in the rat. Evidence for cholinergic mediation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5e88d964-017c-4d33-9de1-e8dc2ad1ad66EnglishSymplectic Elements at Oxford1988Stoessl, ADourish, CIversen, SThe selective NK-3 tachykinin receptor agonist senktide elicited yawning, chewing mouth movements and sexual arousal following subcutaneous administration (0.1-1.0 mg/kg) in the rat. These responses were not significantly affected by the dopamine antagonist haloperidol (0.03 mg/kg) or by 6-hydroxydopamine lesions of the nigrostriatal projection. In contrast, the behaviours were markedly attenuated by the peripheral and central muscarinic antagonist scopolamine (1 mg/kg), but not by the peripheral muscarinic antagonist N-methylscopolamine (1 mg/kg). These findings suggest that stimulation of NK-3 receptors produces yawning, chewing and sexual arousal by directly activating central cholinergic neurons. |
| spellingShingle | Stoessl, A Dourish, C Iversen, S The NK-3 tachykinin agonist senktide elicits yawning and chewing mouth movements following subcutaneous administration in the rat. Evidence for cholinergic mediation. |
| title | The NK-3 tachykinin agonist senktide elicits yawning and chewing mouth movements following subcutaneous administration in the rat. Evidence for cholinergic mediation. |
| title_full | The NK-3 tachykinin agonist senktide elicits yawning and chewing mouth movements following subcutaneous administration in the rat. Evidence for cholinergic mediation. |
| title_fullStr | The NK-3 tachykinin agonist senktide elicits yawning and chewing mouth movements following subcutaneous administration in the rat. Evidence for cholinergic mediation. |
| title_full_unstemmed | The NK-3 tachykinin agonist senktide elicits yawning and chewing mouth movements following subcutaneous administration in the rat. Evidence for cholinergic mediation. |
| title_short | The NK-3 tachykinin agonist senktide elicits yawning and chewing mouth movements following subcutaneous administration in the rat. Evidence for cholinergic mediation. |
| title_sort | nk 3 tachykinin agonist senktide elicits yawning and chewing mouth movements following subcutaneous administration in the rat evidence for cholinergic mediation |
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