Differing impact of preterm birth on the right and left atria in adulthood

<p><strong>Background</strong></p> <p>Preterm birth affects 10% of live births and is associated with an altered left ventricular and right ventricular phenotype and increased cardiovascular disease risk in young adulthood. Because left atrial (LA) and right atrial (RA)...

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Main Authors: Schuermans, A, den Harink, T, Raman, B, Smillie, RW, Alsharqi, M, Mohamed, A, Lapidaire, W, van Deutekom, AW, Leeson, P, Lewandowski, AJ
Format: Journal article
Language:English
Published: American Heart Association 2022
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author Schuermans, A
den Harink, T
Raman, B
Smillie, RW
Alsharqi, M
Mohamed, A
Lapidaire, W
van Deutekom, AW
Leeson, P
Lewandowski, AJ
author_facet Schuermans, A
den Harink, T
Raman, B
Smillie, RW
Alsharqi, M
Mohamed, A
Lapidaire, W
van Deutekom, AW
Leeson, P
Lewandowski, AJ
author_sort Schuermans, A
collection OXFORD
description <p><strong>Background</strong></p> <p>Preterm birth affects 10% of live births and is associated with an altered left ventricular and right ventricular phenotype and increased cardiovascular disease risk in young adulthood. Because left atrial (LA) and right atrial (RA) volume and function are known independent predictors of cardiovascular outcomes, we investigated whether these were altered in preterm‐born young adults.</p></strong> <p><strong>Methods and Results</strong></p> <p>Preterm‐born (n=200) and term‐born (n=266) adults aged 18 to 39 years underwent cardiovascular magnetic resonance imaging. LA and RA maximal and minimal volumes (absolute, indexed to body surface area, and as a ratio to ventricular volumes) were obtained to study atrial morphology, while LA and RA stroke volume, strain, and strain rate were used to assess atrial function. Secondary analyses consisted of between‐group comparisons based on degree of prematurity. Absolute RA volumes and RA volumes indexed to right ventricular volumes were significantly smaller in preterm‐born compared with term‐born adults. In addition, RA reservoir and booster strain were higher in preterm‐born adults, possibly indicating functional compensation for the smaller RA volumes. LA volumes indexed to left ventricular volumes were significantly greater in preterm‐born adults as compared with term‐born adults, although absolute LA volumes were similar between groups. LA and RA changes were observed across gestational ages in the preterm group but were greatest in those born very‐to‐extremely preterm.</p></strong> <p><strong>Conclusions</strong></p> <p>Preterm‐born adults show changes in LA and RA structure and function, which may indicate subclinical cardiovascular disease. Further research into underlying mechanisms, opportunities for interventions, and their prognostic value is warranted.</p>
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spelling oxford-uuid:5e8bc0b8-5877-4136-9770-f12d22b177fb2024-02-08T11:53:05ZDiffering impact of preterm birth on the right and left atria in adulthoodJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5e8bc0b8-5877-4136-9770-f12d22b177fbEnglishSymplectic ElementsAmerican Heart Association2022Schuermans, Aden Harink, TRaman, BSmillie, RWAlsharqi, MMohamed, ALapidaire, Wvan Deutekom, AWLeeson, PLewandowski, AJ<p><strong>Background</strong></p> <p>Preterm birth affects 10% of live births and is associated with an altered left ventricular and right ventricular phenotype and increased cardiovascular disease risk in young adulthood. Because left atrial (LA) and right atrial (RA) volume and function are known independent predictors of cardiovascular outcomes, we investigated whether these were altered in preterm‐born young adults.</p></strong> <p><strong>Methods and Results</strong></p> <p>Preterm‐born (n=200) and term‐born (n=266) adults aged 18 to 39 years underwent cardiovascular magnetic resonance imaging. LA and RA maximal and minimal volumes (absolute, indexed to body surface area, and as a ratio to ventricular volumes) were obtained to study atrial morphology, while LA and RA stroke volume, strain, and strain rate were used to assess atrial function. Secondary analyses consisted of between‐group comparisons based on degree of prematurity. Absolute RA volumes and RA volumes indexed to right ventricular volumes were significantly smaller in preterm‐born compared with term‐born adults. In addition, RA reservoir and booster strain were higher in preterm‐born adults, possibly indicating functional compensation for the smaller RA volumes. LA volumes indexed to left ventricular volumes were significantly greater in preterm‐born adults as compared with term‐born adults, although absolute LA volumes were similar between groups. LA and RA changes were observed across gestational ages in the preterm group but were greatest in those born very‐to‐extremely preterm.</p></strong> <p><strong>Conclusions</strong></p> <p>Preterm‐born adults show changes in LA and RA structure and function, which may indicate subclinical cardiovascular disease. Further research into underlying mechanisms, opportunities for interventions, and their prognostic value is warranted.</p>
spellingShingle Schuermans, A
den Harink, T
Raman, B
Smillie, RW
Alsharqi, M
Mohamed, A
Lapidaire, W
van Deutekom, AW
Leeson, P
Lewandowski, AJ
Differing impact of preterm birth on the right and left atria in adulthood
title Differing impact of preterm birth on the right and left atria in adulthood
title_full Differing impact of preterm birth on the right and left atria in adulthood
title_fullStr Differing impact of preterm birth on the right and left atria in adulthood
title_full_unstemmed Differing impact of preterm birth on the right and left atria in adulthood
title_short Differing impact of preterm birth on the right and left atria in adulthood
title_sort differing impact of preterm birth on the right and left atria in adulthood
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