Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice

Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice

Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism termed parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. FBXO7 (F-box protein only 7) is a subunit of the SCF (SKP1/cullin-1/F-box protein) E3 ubiquitin...

書目詳細資料
Main Authors:	Vingill, S, Brockelt, D, Lancelin, C, Tatenhorst, L, Dontcheva, G, Preisinger, C, Schwedhelm-Domeyer, N, Joseph, S, Mitkovski, M, Goebbels, S, Nave, K, Schulz, J, Marquardt, T, Lingor, P, Stegmüller, J
格式:	Journal article
語言:	English
出版:	EMBO Press 2016

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