Decreased thickness and integrity of the macular elastic layer of Bruch's membrane correspond to the distribution of lesions associated with age-related macular degeneration.

Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. In its severest form, choroidal neovessels breach the macular Bruch's membrane, an extracellular matrix compartment comprised of elastin and collagen laminae, and grow into the retina. We sought to determine...

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Bibliographic Details
Main Authors: Chong, N, Keonin, J, Luthert, P, Frennesson, C, Weingeist, D, Wolf, R, Mullins, R, Hageman, G
Format: Journal article
Language:English
Published: 2005