Efficiency of de novo centromere formation in human artificial chromosomes.

Efficiency of de novo centromere formation in human artificial chromosomes.

In a comparative study, we show that human artificial chromosome (HAC) vectors based on alpha-satellite (alphoid) DNA from chromosome 17 but not the Y chromosome regularly form HACs in HT1080 human cells. We constructed four structurally similar HAC vectors, two with chromosome 17 or Y alphoid DNA (...

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Bibliographic Details
Main Authors:	Mejía, J, Alazami, A, Willmott, A, Marschall, P, Levy, E, Earnshaw, W, Larin, Z
Format:	Journal article
Language:	English
Published:	2002

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