The Met1-linked ubiquitin machinery: Emerging themes of (de)regulation
The linear ubiquitin chain assembly complex, LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1) linked polyubiquitin (also referred to as linear ubiquitin). A decade after LUBAC was discovered as a cellular activity of unknown function, there are now many lines of evi...
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| Format: | Journal article |
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Elsevier
2017
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| _version_ | 1826274953837674496 |
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| author | Hrdinka, M Gyrd-Hansen, M |
| author_facet | Hrdinka, M Gyrd-Hansen, M |
| author_sort | Hrdinka, M |
| collection | OXFORD |
| description | The linear ubiquitin chain assembly complex, LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1) linked polyubiquitin (also referred to as linear ubiquitin). A decade after LUBAC was discovered as a cellular activity of unknown function, there are now many lines of evidence connecting Met1-linked polyubiquitin to NF-B signaling, cell death, inflammation, immunity and cancer. We now know that Met1-linked polyubiquitin has potent signaling functions and that its deregulation is connected to disease. Indeed, mutations and deficiencies in several factors involved in conjugation and deconjugation of Met1-linked polyubiquitin have been implicated in immune-related disorders. Here, we discuss current knowledge and recent insights into the role and regulation of Met1-linked polyubiquitin, with an emphasis on the mechanisms controlling the function of LUBAC. |
| first_indexed | 2024-03-06T22:51:20Z |
| format | Journal article |
| id | oxford-uuid:5ee1ec08-9d7c-42fd-a115-e626d1afb073 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:51:20Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:5ee1ec08-9d7c-42fd-a115-e626d1afb0732022-03-26T17:43:29ZThe Met1-linked ubiquitin machinery: Emerging themes of (de)regulationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5ee1ec08-9d7c-42fd-a115-e626d1afb073Symplectic Elements at OxfordElsevier2017Hrdinka, MGyrd-Hansen, MThe linear ubiquitin chain assembly complex, LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1) linked polyubiquitin (also referred to as linear ubiquitin). A decade after LUBAC was discovered as a cellular activity of unknown function, there are now many lines of evidence connecting Met1-linked polyubiquitin to NF-B signaling, cell death, inflammation, immunity and cancer. We now know that Met1-linked polyubiquitin has potent signaling functions and that its deregulation is connected to disease. Indeed, mutations and deficiencies in several factors involved in conjugation and deconjugation of Met1-linked polyubiquitin have been implicated in immune-related disorders. Here, we discuss current knowledge and recent insights into the role and regulation of Met1-linked polyubiquitin, with an emphasis on the mechanisms controlling the function of LUBAC. |
| spellingShingle | Hrdinka, M Gyrd-Hansen, M The Met1-linked ubiquitin machinery: Emerging themes of (de)regulation |
| title | The Met1-linked ubiquitin machinery: Emerging themes of (de)regulation |
| title_full | The Met1-linked ubiquitin machinery: Emerging themes of (de)regulation |
| title_fullStr | The Met1-linked ubiquitin machinery: Emerging themes of (de)regulation |
| title_full_unstemmed | The Met1-linked ubiquitin machinery: Emerging themes of (de)regulation |
| title_short | The Met1-linked ubiquitin machinery: Emerging themes of (de)regulation |
| title_sort | met1 linked ubiquitin machinery emerging themes of de regulation |
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