Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase

A paucity of novel acting antibacterials is in development to treat the rising threat of antimicrobial resistance, particularly in Gram-negative hospital pathogens, which has led to renewed efforts in antibiotic drug discovery. Fluoroquinolones are broad-spectrum antibacterials that target DNA gyras...

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Manylion Llyfryddiaeth
Prif Awduron: Chan, P, Germe, T, Bax, B, Huang, J, Thalji, R, Bacqué, E, Checchia, A, Chen, D, Cui, H, Ding, X, Ingraham, K, McCloskey, L, Raha, K, Srikannathasan, V, Maxwell, A, Stavenger, R
Fformat: Journal article
Iaith:English
Cyhoeddwyd: National Academy of Sciences 2017