Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ+IL-17+ polyfunctional T cells that mediate rejection of murine tumors.

Immunotherapy with PI3K inhibitor and Toll-like receptor agonist induces IFN-γ+IL-17+ polyfunctional T cells that mediate rejection of murine tumors.

The immunosuppressive microenvironment in tumors hampers the induction of antitumor immunity by vaccines or immunotherapies. Toll-like receptor (TLR) ligands have the potential to treat tumors, but they can exert a mixture of positive and negative effects on inflammation in the tumor microenvironmen...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Marshall, N, Galvin, K, Corcoran, A, Boon, L, Higgs, R, Mills, K
Format:	Journal article
Język:	English
Wydane:	2012

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