Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials.
The objective of this review was to determine the effectiveness, adverse effects and acceptability of folate in the treatment of depression. Electronic databases (Cochrane Controlled Trials Register and the Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register) and refer...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2004
|
| _version_ | 1826274968293343232 |
|---|---|
| author | Taylor, M Carney, S Goodwin, G Geddes, J |
| author_facet | Taylor, M Carney, S Goodwin, G Geddes, J |
| author_sort | Taylor, M |
| collection | OXFORD |
| description | The objective of this review was to determine the effectiveness, adverse effects and acceptability of folate in the treatment of depression. Electronic databases (Cochrane Controlled Trials Register and the Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register) and reference lists were searched, and authors, experts and pharmaceutical companies contacted to identify randomized controlled trials that compared treatment with folic acid or 5'-methyltetrahydrofolic acid to an alternative treatment, for patients with a diagnosis of depressive disorder. Three randomized trials (247 participants) were included. Two studies assessed the use of folate in addition to other treatment, and found that adding folate reduced Hamilton Depression Rating Scale (HDRS) scores on average by a further 2.65 points [95% confidence interval (CI) 0.38-4.93]. Fewer patients treated with folate experienced a reduction in their HDRS score of less than 50% at 10 weeks (relative risk 0.47, 95% CI 0.24-0.92). The remaining study found no statistically significant difference when folate alone was compared with trazodone. The identified trials did not find evidence of any problems with the acceptability or safety of folate. The limited available evidence suggests folate may have a potential role as a supplement to other treatment for depression. It is currently unclear if this is the case both for people with normal folate levels, and for those with folate deficiency. |
| first_indexed | 2024-03-06T22:51:33Z |
| format | Journal article |
| id | oxford-uuid:5ef0e38e-b532-42a0-888f-211ad4b8018e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:51:33Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:5ef0e38e-b532-42a0-888f-211ad4b8018e2022-03-26T17:43:54ZFolate for depressive disorders: systematic review and meta-analysis of randomized controlled trials.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5ef0e38e-b532-42a0-888f-211ad4b8018eEnglishSymplectic Elements at Oxford2004Taylor, MCarney, SGoodwin, GGeddes, JThe objective of this review was to determine the effectiveness, adverse effects and acceptability of folate in the treatment of depression. Electronic databases (Cochrane Controlled Trials Register and the Cochrane Collaboration Depression, Anxiety and Neurosis Controlled Trials Register) and reference lists were searched, and authors, experts and pharmaceutical companies contacted to identify randomized controlled trials that compared treatment with folic acid or 5'-methyltetrahydrofolic acid to an alternative treatment, for patients with a diagnosis of depressive disorder. Three randomized trials (247 participants) were included. Two studies assessed the use of folate in addition to other treatment, and found that adding folate reduced Hamilton Depression Rating Scale (HDRS) scores on average by a further 2.65 points [95% confidence interval (CI) 0.38-4.93]. Fewer patients treated with folate experienced a reduction in their HDRS score of less than 50% at 10 weeks (relative risk 0.47, 95% CI 0.24-0.92). The remaining study found no statistically significant difference when folate alone was compared with trazodone. The identified trials did not find evidence of any problems with the acceptability or safety of folate. The limited available evidence suggests folate may have a potential role as a supplement to other treatment for depression. It is currently unclear if this is the case both for people with normal folate levels, and for those with folate deficiency. |
| spellingShingle | Taylor, M Carney, S Goodwin, G Geddes, J Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials. |
| title | Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials. |
| title_full | Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials. |
| title_fullStr | Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials. |
| title_full_unstemmed | Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials. |
| title_short | Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials. |
| title_sort | folate for depressive disorders systematic review and meta analysis of randomized controlled trials |
| work_keys_str_mv | AT taylorm folatefordepressivedisorderssystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT carneys folatefordepressivedisorderssystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT goodwing folatefordepressivedisorderssystematicreviewandmetaanalysisofrandomizedcontrolledtrials AT geddesj folatefordepressivedisorderssystematicreviewandmetaanalysisofrandomizedcontrolledtrials |