Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events
BACKGROUND:Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk. METHODS:A variant at chromosome 9p21 (rs13...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
American Heart Association
2019
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| _version_ | 1797071326710595584 |
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| author | Patel, RS Schmidt, AF Tragante, V McCubrey, RO Holmes, MV Howe, LJ Direk, K Åkerblom, A Leander, K Virani, SS Kaminski, KA Muehlschlegel, JD Dubé, M-P Allayee, H Almgren, P Alver, M Baranova, EV Behlouli, H Boeckx, B Braund, PS Breitling, LP Delgado, G Duarte, NE Dufresne, L Eriksson, N Foco, L Gijsberts, CM Gong, Y Hartiala, J Heydarpour, M Hubacek, JA Kleber, M Kofink, D Kuukasjärvi, P Lee, V-V Leiherer, A Lenzini, PA Levin, D Lyytikäinen, L-P Martinelli, N Mons, U Nelson, CP Nikus, K Pilbrow, AP Ploski, R Sun, YV Tanck, MWT Tang, WHW Trompet, S Van Der Laan, SW Van Setten, J Vilmundarson, RO Anselmi, C Vlachopoulou, E Boerwinkle, E Briguori, C Carlquist, JF Carruthers, KF Casu, G Deanfield, J Deloukas, P Dudbridge, F Fitzpatrick, N Gigante, B James, S Lokki, M-L Lotufo, PA Marziliano, N Mordi, IR Muhlestein, JB Newton-Cheh, C Pitha, J Saely, CH Samman-Tahhan, A Sandesara, PB Teren, A Timmis, A Van De Werf, F Wauters, E Wilde, AAM Ford, I Stott, DJ Algra, A Andreassi, MG Ardissino, D Arsenault, BJ Ballantyne, CM Bergmeijer, TO Bezzina, CR Body, SC Bogaty, P De Borst, GJ Brenner, H Burkhardt, R Carpeggiani, C Condorelli, G Cooper-Dehoff, RM Cresci, S De Faire, U Doughty, RN Drexel, H Engert, JC Fox, KAA Girelli, D Hagström, E Hazen, SL Held, C Hemingway, H Hoefer, IE Hovingh, GK Johnson, JA De Jong, PA Jukema, JW Kaczor, MP Kähönen, M Kettner, J Kiliszek, M Klungel, OH Lagerqvist, B Lambrechts, D Laurikka, JO Lehtimäki, T Lindholm, D Mahmoodi, BK Der Zee, AH McPherson, R Melander, O Metspalu, A Pepinski, W Olivieri, O Opolski, G Palmer, CN Pasterkamp, G Pepine, CJ Pereira, AC Pilote, L Quyyumi, AA Richards, AM Sanak, M Scholz, M Siegbahn, A Sinisalo, J Smith, JG Spertus, JA Stewart, AFR Szczeklik, W Szpakowicz, A Berg, JM Thanassoulis, G Thiery, J Van Der Graaf, Y Visseren, FLJ Waltenberger, J Van Der Harst, P Tardif, J-C Sattar, N Lang, CC Paré, G Brophy, JM Anderson, JL März, W Wallentin, L Cameron, VA Horne, BD Samani, NJ Hingorani, AD Asselbergs, FW |
| author_facet | Patel, RS Schmidt, AF Tragante, V McCubrey, RO Holmes, MV Howe, LJ Direk, K Åkerblom, A Leander, K Virani, SS Kaminski, KA Muehlschlegel, JD Dubé, M-P Allayee, H Almgren, P Alver, M Baranova, EV Behlouli, H Boeckx, B Braund, PS Breitling, LP Delgado, G Duarte, NE Dufresne, L Eriksson, N Foco, L Gijsberts, CM Gong, Y Hartiala, J Heydarpour, M Hubacek, JA Kleber, M Kofink, D Kuukasjärvi, P Lee, V-V Leiherer, A Lenzini, PA Levin, D Lyytikäinen, L-P Martinelli, N Mons, U Nelson, CP Nikus, K Pilbrow, AP Ploski, R Sun, YV Tanck, MWT Tang, WHW Trompet, S Van Der Laan, SW Van Setten, J Vilmundarson, RO Anselmi, C Vlachopoulou, E Boerwinkle, E Briguori, C Carlquist, JF Carruthers, KF Casu, G Deanfield, J Deloukas, P Dudbridge, F Fitzpatrick, N Gigante, B James, S Lokki, M-L Lotufo, PA Marziliano, N Mordi, IR Muhlestein, JB Newton-Cheh, C Pitha, J Saely, CH Samman-Tahhan, A Sandesara, PB Teren, A Timmis, A Van De Werf, F Wauters, E Wilde, AAM Ford, I Stott, DJ Algra, A Andreassi, MG Ardissino, D Arsenault, BJ Ballantyne, CM Bergmeijer, TO Bezzina, CR Body, SC Bogaty, P De Borst, GJ Brenner, H Burkhardt, R Carpeggiani, C Condorelli, G Cooper-Dehoff, RM Cresci, S De Faire, U Doughty, RN Drexel, H Engert, JC Fox, KAA Girelli, D Hagström, E Hazen, SL Held, C Hemingway, H Hoefer, IE Hovingh, GK Johnson, JA De Jong, PA Jukema, JW Kaczor, MP Kähönen, M Kettner, J Kiliszek, M Klungel, OH Lagerqvist, B Lambrechts, D Laurikka, JO Lehtimäki, T Lindholm, D Mahmoodi, BK Der Zee, AH McPherson, R Melander, O Metspalu, A Pepinski, W Olivieri, O Opolski, G Palmer, CN Pasterkamp, G Pepine, CJ Pereira, AC Pilote, L Quyyumi, AA Richards, AM Sanak, M Scholz, M Siegbahn, A Sinisalo, J Smith, JG Spertus, JA Stewart, AFR Szczeklik, W Szpakowicz, A Berg, JM Thanassoulis, G Thiery, J Van Der Graaf, Y Visseren, FLJ Waltenberger, J Van Der Harst, P Tardif, J-C Sattar, N Lang, CC Paré, G Brophy, JM Anderson, JL März, W Wallentin, L Cameron, VA Horne, BD Samani, NJ Hingorani, AD Asselbergs, FW |
| author_sort | Patel, RS |
| collection | OXFORD |
| description | BACKGROUND:Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk. METHODS:A variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103,357 Europeans with established CHD at baseline from the GENIUS-CHD Consortium (73.1% male, mean age 62.9 years). The primary outcome, subsequent CHD death or myocardial infarction (CHD death/MI), occurred in 13,040 of the 93,115 participants with available outcome data. Effect estimates were compared to case/control risk obtained from CARDIoGRAMPlusC4D including 47,222 CHD cases and 122,264 controls free of CHD. RESULTS:Meta-analyses revealed no significant association between chromosome 9p21 and the primary outcome of CHD death/MI among those with established CHD at baseline (GENIUS-CHD OR 1.02; 95% CI 0.99-1.05). This contrasted with a strong association in CARDIoGRAMPlusC4D OR 1.20; 95% CI 1.18-1.22; p for interaction Conclusions: In contrast to studies comparing individuals with CHD to disease free controls, we found no clear association between genetic variation at chromosome 9p21 and risk of subsequent acute CHD events when all individuals had CHD at baseline. However, the association with subsequent revascularization may support the postulated mechanism of chromosome 9p21 for promoting atheroma development. |
| first_indexed | 2024-03-06T22:51:35Z |
| format | Journal article |
| id | oxford-uuid:5ef69c52-32c8-4e58-9825-f34a84457793 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:51:35Z |
| publishDate | 2019 |
| publisher | American Heart Association |
| record_format | dspace |
| spelling | oxford-uuid:5ef69c52-32c8-4e58-9825-f34a844577932022-03-26T17:44:30ZAssociation of Chromosome 9p21 With Subsequent Coronary Heart Disease EventsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5ef69c52-32c8-4e58-9825-f34a84457793EnglishSymplectic Elements at OxfordAmerican Heart Association2019Patel, RSSchmidt, AFTragante, VMcCubrey, ROHolmes, MVHowe, LJDirek, KÅkerblom, ALeander, KVirani, SSKaminski, KAMuehlschlegel, JDDubé, M-PAllayee, HAlmgren, PAlver, MBaranova, EVBehlouli, HBoeckx, BBraund, PSBreitling, LPDelgado, GDuarte, NEDufresne, LEriksson, NFoco, LGijsberts, CMGong, YHartiala, JHeydarpour, MHubacek, JAKleber, MKofink, DKuukasjärvi, PLee, V-VLeiherer, ALenzini, PALevin, DLyytikäinen, L-PMartinelli, NMons, UNelson, CPNikus, KPilbrow, APPloski, RSun, YVTanck, MWTTang, WHWTrompet, SVan Der Laan, SWVan Setten, JVilmundarson, ROAnselmi, CVlachopoulou, EBoerwinkle, EBriguori, CCarlquist, JFCarruthers, KFCasu, GDeanfield, JDeloukas, PDudbridge, FFitzpatrick, NGigante, BJames, SLokki, M-LLotufo, PAMarziliano, NMordi, IRMuhlestein, JBNewton-Cheh, CPitha, JSaely, CHSamman-Tahhan, ASandesara, PBTeren, ATimmis, AVan De Werf, FWauters, EWilde, AAMFord, IStott, DJAlgra, AAndreassi, MGArdissino, DArsenault, BJBallantyne, CMBergmeijer, TOBezzina, CRBody, SCBogaty, PDe Borst, GJBrenner, HBurkhardt, RCarpeggiani, CCondorelli, GCooper-Dehoff, RMCresci, SDe Faire, UDoughty, RNDrexel, HEngert, JCFox, KAAGirelli, DHagström, EHazen, SLHeld, CHemingway, HHoefer, IEHovingh, GKJohnson, JADe Jong, PAJukema, JWKaczor, MPKähönen, MKettner, JKiliszek, MKlungel, OHLagerqvist, BLambrechts, DLaurikka, JOLehtimäki, TLindholm, DMahmoodi, BKDer Zee, AHMcPherson, RMelander, OMetspalu, APepinski, WOlivieri, OOpolski, GPalmer, CNPasterkamp, GPepine, CJPereira, ACPilote, LQuyyumi, AARichards, AMSanak, MScholz, MSiegbahn, ASinisalo, JSmith, JGSpertus, JAStewart, AFRSzczeklik, WSzpakowicz, ABerg, JMThanassoulis, GThiery, JVan Der Graaf, YVisseren, FLJWaltenberger, JVan Der Harst, PTardif, J-CSattar, NLang, CCParé, GBrophy, JMAnderson, JLMärz, WWallentin, LCameron, VAHorne, BDSamani, NJHingorani, ADAsselbergs, FWBACKGROUND:Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk. METHODS:A variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103,357 Europeans with established CHD at baseline from the GENIUS-CHD Consortium (73.1% male, mean age 62.9 years). The primary outcome, subsequent CHD death or myocardial infarction (CHD death/MI), occurred in 13,040 of the 93,115 participants with available outcome data. Effect estimates were compared to case/control risk obtained from CARDIoGRAMPlusC4D including 47,222 CHD cases and 122,264 controls free of CHD. RESULTS:Meta-analyses revealed no significant association between chromosome 9p21 and the primary outcome of CHD death/MI among those with established CHD at baseline (GENIUS-CHD OR 1.02; 95% CI 0.99-1.05). This contrasted with a strong association in CARDIoGRAMPlusC4D OR 1.20; 95% CI 1.18-1.22; p for interaction Conclusions: In contrast to studies comparing individuals with CHD to disease free controls, we found no clear association between genetic variation at chromosome 9p21 and risk of subsequent acute CHD events when all individuals had CHD at baseline. However, the association with subsequent revascularization may support the postulated mechanism of chromosome 9p21 for promoting atheroma development. |
| spellingShingle | Patel, RS Schmidt, AF Tragante, V McCubrey, RO Holmes, MV Howe, LJ Direk, K Åkerblom, A Leander, K Virani, SS Kaminski, KA Muehlschlegel, JD Dubé, M-P Allayee, H Almgren, P Alver, M Baranova, EV Behlouli, H Boeckx, B Braund, PS Breitling, LP Delgado, G Duarte, NE Dufresne, L Eriksson, N Foco, L Gijsberts, CM Gong, Y Hartiala, J Heydarpour, M Hubacek, JA Kleber, M Kofink, D Kuukasjärvi, P Lee, V-V Leiherer, A Lenzini, PA Levin, D Lyytikäinen, L-P Martinelli, N Mons, U Nelson, CP Nikus, K Pilbrow, AP Ploski, R Sun, YV Tanck, MWT Tang, WHW Trompet, S Van Der Laan, SW Van Setten, J Vilmundarson, RO Anselmi, C Vlachopoulou, E Boerwinkle, E Briguori, C Carlquist, JF Carruthers, KF Casu, G Deanfield, J Deloukas, P Dudbridge, F Fitzpatrick, N Gigante, B James, S Lokki, M-L Lotufo, PA Marziliano, N Mordi, IR Muhlestein, JB Newton-Cheh, C Pitha, J Saely, CH Samman-Tahhan, A Sandesara, PB Teren, A Timmis, A Van De Werf, F Wauters, E Wilde, AAM Ford, I Stott, DJ Algra, A Andreassi, MG Ardissino, D Arsenault, BJ Ballantyne, CM Bergmeijer, TO Bezzina, CR Body, SC Bogaty, P De Borst, GJ Brenner, H Burkhardt, R Carpeggiani, C Condorelli, G Cooper-Dehoff, RM Cresci, S De Faire, U Doughty, RN Drexel, H Engert, JC Fox, KAA Girelli, D Hagström, E Hazen, SL Held, C Hemingway, H Hoefer, IE Hovingh, GK Johnson, JA De Jong, PA Jukema, JW Kaczor, MP Kähönen, M Kettner, J Kiliszek, M Klungel, OH Lagerqvist, B Lambrechts, D Laurikka, JO Lehtimäki, T Lindholm, D Mahmoodi, BK Der Zee, AH McPherson, R Melander, O Metspalu, A Pepinski, W Olivieri, O Opolski, G Palmer, CN Pasterkamp, G Pepine, CJ Pereira, AC Pilote, L Quyyumi, AA Richards, AM Sanak, M Scholz, M Siegbahn, A Sinisalo, J Smith, JG Spertus, JA Stewart, AFR Szczeklik, W Szpakowicz, A Berg, JM Thanassoulis, G Thiery, J Van Der Graaf, Y Visseren, FLJ Waltenberger, J Van Der Harst, P Tardif, J-C Sattar, N Lang, CC Paré, G Brophy, JM Anderson, JL März, W Wallentin, L Cameron, VA Horne, BD Samani, NJ Hingorani, AD Asselbergs, FW Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events |
| title | Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events |
| title_full | Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events |
| title_fullStr | Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events |
| title_full_unstemmed | Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events |
| title_short | Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events |
| title_sort | association of chromosome 9p21 with subsequent coronary heart disease events |
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associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT pepinecj associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT pereiraac associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT pilotel associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT quyyumiaa associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT richardsam associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT sanakm associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT scholzm associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT siegbahna associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT sinisaloj associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT smithjg associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT spertusja associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT stewartafr associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT szczeklikw associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT szpakowicza associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT bergjm associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT thanassoulisg associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT thieryj associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT vandergraafy associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT visserenflj associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT waltenbergerj associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT vanderharstp associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT tardifjc associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT sattarn associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT langcc associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT pareg associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT brophyjm associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT andersonjl associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT marzw associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT wallentinl associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT cameronva associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT hornebd associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT samaninj associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT hingoraniad associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents AT asselbergsfw associationofchromosome9p21withsubsequentcoronaryheartdiseaseevents |