Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets.

Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets.

OBJECTIVE: To document the properties of the voltage-gated ion channels in human pancreatic alpha-cells and their role in glucagon release. RESEARCH DESIGN AND METHODS: Glucagon release was measured from intact islets. [Ca(2+)](i) was recorded in cells showing spontaneous activity at 1 mmol/l glucos...

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Bibliographic Details
Main Authors: Ramracheya, R, Ward, C, Shigeto, M, Walker, J, Amisten, S, Zhang, Q, Johnson, P, Rorsman, P, Braun, M
Format: Journal article
Language:English
Published: 2010

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