Motor practice and neurophysiological adaptation in the cerebellum: a positron tomography study.
We have used positron tomography (PET) to demonstrate that some parts of the motor system exhibit physiological adaptation during the repeated performance of a simple motor task, but others do not. In contrast to the primary sensori-motor cortex, the cerebellum exhibits a decrease in physiological a...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1992
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| _version_ | 1797071374830796800 |
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| author | Friston, K Frith, C Passingham, R Liddle, P Frackowiak, R |
| author_facet | Friston, K Frith, C Passingham, R Liddle, P Frackowiak, R |
| author_sort | Friston, K |
| collection | OXFORD |
| description | We have used positron tomography (PET) to demonstrate that some parts of the motor system exhibit physiological adaptation during the repeated performance of a simple motor task, but others do not. In contrast to the primary sensori-motor cortex, the cerebellum exhibits a decrease in physiological activation (increases in regional blood flow during performance) with practice. A new application of factorial experimental design to PET activation studies was used to make these measurements in four normal males. This design allowed adaptation to be examined by testing for an interaction between regional cerebral blood flow (rCBF) increases brought about by a motor task and the number of trials (time). These findings are interpreted as the neurophysiological correlates of synaptic changes in the cerebellum associated with motor learning in man. |
| first_indexed | 2024-03-06T22:52:18Z |
| format | Journal article |
| id | oxford-uuid:5f343d97-8ee2-4aa2-b6e0-9f6c2b5d5e82 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:52:18Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:5f343d97-8ee2-4aa2-b6e0-9f6c2b5d5e822022-03-26T17:45:24ZMotor practice and neurophysiological adaptation in the cerebellum: a positron tomography study.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5f343d97-8ee2-4aa2-b6e0-9f6c2b5d5e82EnglishSymplectic Elements at Oxford1992Friston, KFrith, CPassingham, RLiddle, PFrackowiak, RWe have used positron tomography (PET) to demonstrate that some parts of the motor system exhibit physiological adaptation during the repeated performance of a simple motor task, but others do not. In contrast to the primary sensori-motor cortex, the cerebellum exhibits a decrease in physiological activation (increases in regional blood flow during performance) with practice. A new application of factorial experimental design to PET activation studies was used to make these measurements in four normal males. This design allowed adaptation to be examined by testing for an interaction between regional cerebral blood flow (rCBF) increases brought about by a motor task and the number of trials (time). These findings are interpreted as the neurophysiological correlates of synaptic changes in the cerebellum associated with motor learning in man. |
| spellingShingle | Friston, K Frith, C Passingham, R Liddle, P Frackowiak, R Motor practice and neurophysiological adaptation in the cerebellum: a positron tomography study. |
| title | Motor practice and neurophysiological adaptation in the cerebellum: a positron tomography study. |
| title_full | Motor practice and neurophysiological adaptation in the cerebellum: a positron tomography study. |
| title_fullStr | Motor practice and neurophysiological adaptation in the cerebellum: a positron tomography study. |
| title_full_unstemmed | Motor practice and neurophysiological adaptation in the cerebellum: a positron tomography study. |
| title_short | Motor practice and neurophysiological adaptation in the cerebellum: a positron tomography study. |
| title_sort | motor practice and neurophysiological adaptation in the cerebellum a positron tomography study |
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