The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs

The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs

Purine nucleoside phosphorylases (PNPs) play an important role in the blood fluke parasite Schistosoma mansoni as a key enzyme of the purine salvage pathway. Here we present the structural and kinetic characterization of a new PNP isoform from S. mansoni, SmPNP2. Thermofluorescence screening of diff...

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Dettagli Bibliografici
Autori principali:	Torini, JR, Romanello, L, Batista, FAH, Serrão, VHB, Faheem, M, Zeraik, AE, Bird, L, Nettleship, J, Reddivari, Y, Owens, R, Demarco, R, Borges, JC, Brandão-Neto, J, Pereira, HD
Natura:	Journal article
Lingua:	English
Pubblicazione:	Public Library of Science 2018

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