A cognitive neuropsychological model of antidepressant drug action.
The psychological mechanisms by which antidepressant drugs act to improve mood remain underspecified. In this paper we consider the evidence to suggest that early changes in emotional processing underlie subsequent mood improvement following antidepressant treatment. Negative biases in information p...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797071398228721664 |
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| author | Pringle, A Browning, M Cowen, P Harmer, C |
| author_facet | Pringle, A Browning, M Cowen, P Harmer, C |
| author_sort | Pringle, A |
| collection | OXFORD |
| description | The psychological mechanisms by which antidepressant drugs act to improve mood remain underspecified. In this paper we consider the evidence to suggest that early changes in emotional processing underlie subsequent mood improvement following antidepressant treatment. Negative biases in information processing are consistently found in depression, and we argue that primary mode of action of antidepressant drugs may be to remediate these biases providing a more positive social environment in which the patient can relearn emotional associations fostering later improvement in mood. Evidence from behavioural and functional magnetic resonance imaging studies supports this hypothesis. Experimental medicine models developed under this premise have the potential to screen for new treatments, to predict individual treatment response and to consider the effects of pharmacological vs psychological treatments. |
| first_indexed | 2024-03-06T22:52:38Z |
| format | Journal article |
| id | oxford-uuid:5f50cfcf-b37e-439b-b0ff-ff5ad6aa4071 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:52:38Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:5f50cfcf-b37e-439b-b0ff-ff5ad6aa40712022-03-26T17:46:07ZA cognitive neuropsychological model of antidepressant drug action.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5f50cfcf-b37e-439b-b0ff-ff5ad6aa4071EnglishSymplectic Elements at Oxford2011Pringle, ABrowning, MCowen, PHarmer, CThe psychological mechanisms by which antidepressant drugs act to improve mood remain underspecified. In this paper we consider the evidence to suggest that early changes in emotional processing underlie subsequent mood improvement following antidepressant treatment. Negative biases in information processing are consistently found in depression, and we argue that primary mode of action of antidepressant drugs may be to remediate these biases providing a more positive social environment in which the patient can relearn emotional associations fostering later improvement in mood. Evidence from behavioural and functional magnetic resonance imaging studies supports this hypothesis. Experimental medicine models developed under this premise have the potential to screen for new treatments, to predict individual treatment response and to consider the effects of pharmacological vs psychological treatments. |
| spellingShingle | Pringle, A Browning, M Cowen, P Harmer, C A cognitive neuropsychological model of antidepressant drug action. |
| title | A cognitive neuropsychological model of antidepressant drug action. |
| title_full | A cognitive neuropsychological model of antidepressant drug action. |
| title_fullStr | A cognitive neuropsychological model of antidepressant drug action. |
| title_full_unstemmed | A cognitive neuropsychological model of antidepressant drug action. |
| title_short | A cognitive neuropsychological model of antidepressant drug action. |
| title_sort | cognitive neuropsychological model of antidepressant drug action |
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