Exploring the potential of iminosugars as antivirals for Crimean-Congo haemorrhagic fever virus, using the surrogate Hazara virus: liquid-chromatography-based mapping of viral N-glycosylation and in vitro antiviral assays

Exploring the potential of iminosugars as antivirals for Crimean-Congo haemorrhagic fever virus, using the surrogate Hazara virus: liquid-chromatography-based mapping of viral N-glycosylation and in vitro antiviral assays

Crimean-Congo haemorrhagic fever virus (CCHFV) is a pathogen of increasing public health concern, being a widely distributed arbovirus and the causative agent of the potentially fatal Crimean-Congo haemorrhagic fever. Hazara virus (HAZV) is a genetically and serologically related virus that has been...

Full description

Bibliographic Details
Main Authors:	Tyrrell, BE, Kumar, A, Gangadharan, B, Alonzi, D, Brun, J, Hill, M, Bharucha, T, Bosworth, A, Graham, V, Dowall, S, Miller, JL, Zitzmann, N
Format:	Journal article
Language:	English
Published:	MDPI 2023

Similar Items

Exploring the Potential of Iminosugars as Antivirals for Crimean-Congo Haemorrhagic Fever Virus, Using the Surrogate Hazara Virus: Liquid-Chromatography-Based Mapping of Viral N-Glycosylation and In Vitro Antiviral Assays
by: Beatrice E. Tyrrell, et al.
Published: (2023-03-01)

Antiviral effects of deoxynojirimycin (DNJ)-based iminosugars in dengue virus-infected primary dendritic cells
by: Perera, N, et al.
Published: (2022)

Mechanisms of antiviral activity of iminosugars against dengue virus
by: Miller, JL, et al.
Published: (2018)

Iminosugar antivirals: the therapeutic sweet spot
by: Alonzi, D, et al.
Published: (2017)

Similarities in Antiviral Humoral Immune Response to Nucleocapsid Proteins of Hazara and Crimean–Congo Hemorrhagic Fever Virus
by: Merve Kalkan-Yazıcı, et al.
Published: (2020-06-01)

Antiviral effects of amantadine and iminosugar derivatives against hepatitis C virus.
by: Steinmann, E, et al.
Published: (2007)

Strain-specific antiviral activity of iminosugars against human influenza A viruses.
by: Hussain, S, et al.
Published: (2015)

Study of the mechanism of antiviral action of iminosugar derivatives against bovine viral diarrhea virus.
by: Durantel, D, et al.
Published: (2001)

Antiviral effects of an iminosugar derivative on flavivirus infections.
by: Wu, S, et al.
Published: (2002)

A Novel Iminosugar UV-12 with Activity against the Diverse Viruses Influenza and Dengue (Novel Iminosugar Antiviral for Influenza and Dengue)
by: Kelly L. Warfield, et al.
Published: (2015-05-01)

Antiviral and immunomodulatory activities of iminosugars: candidate therapeutics for arbovirus infections
by: Tyrrell, B
Published: (2018)

Structures of mammalian ER α-glucosidase II capture the binding modes of broad-spectrum iminosugar antivirals
by: Caputo, A, et al.
Published: (2016)

The crystal structure of the Hazara virus nucleocapsid protein
by: Surtees, R, et al.
Published: (2015)

Serological and Virological Evidence of Crimean-Congo Haemorrhagic Fever Virus Circulation in the Human Population of Borno State, Northeastern Nigeria.
by: David N Bukbuk, et al.
Published: (2016-12-01)

Crimean-Congo Hemorrhagic Fever Virus: Current Advances and Future Prospects of Antiviral Strategies
by: Shiyu Dai, et al.
Published: (2021-06-01)

Bypass of quality control in protein folding pathways induces specific misfolding of HIV envelope V2 loop: implications for iminosugars as antivirals
by: Spiro, S, et al.
Published: (2014)

Minimal in vivo efficacy of iminosugars in a lethal ebola virus guinea pig model
by: Miller, J, et al.
Published: (2016)

Crimean-Congo haemorrhagic fever virus in Kazakhstan (1948-2013)
by: Talgat Nurmakhanov, et al.
Published: (2015-09-01)

Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4
by: Warfield, KL, et al.
Published: (2016)

Iminosugars counteract the downregulation of the interferon gamma receptor by dengue virus
by: Miller, J, et al.
Published: (2019)

Hazara virus and Crimean-Congo Hemorrhagic Fever Virus show a different pattern of entry in fully-polarized Caco-2 cell line.
by: Vanessa Monteil, et al.
Published: (2020-11-01)

Minimal In Vivo Efficacy of Iminosugars in a Lethal Ebola Virus Guinea Pig Model.
by: Joanna L Miller, et al.
Published: (2016-01-01)

Glycobiology against viruses: Antiviral drug discovery
by: Zitzmann, N, et al.
Published: (2006)

First evidence of Crimean‐Congo haemorrhagic fever virus circulation in Bosnia and Herzegovina
by: Lejla Satrovic, et al.
Published: (2022-05-01)

Seroepidemiological and molecular investigations of infections with Crimean–Congo haemorrhagic fever virus in Kazakhstan
by: Karlygash Abdiyeva, et al.
Published: (2019-01-01)

Evidence of Crimean-Congo Haemorrhagic Fever Virus Occurrence in Ixodidae Ticks of Armenia
by: Hasmik Gevorgyan, et al.
Published: (2018-10-01)

The bovine viral diarrhoea virus: a model for the study of antiviral molecules interfering with N-glycosylation and folding of envelope glycoprotein
by: Durantel, D, et al.
Published: (2015)

Crimean-Congo Haemorrhagic Fever
by: Hürrem BODUR
Published: (2009-03-01)

Iminosugars inhibit dengue virus production via inhibition of ER alpha-glucosidases – not glycolipid processing enzymes
by: Sayce, AC, et al.
Published: (2016)

Sero-epidemiological survey of Crimean-Congo hemorrhagic fever virus in Tunisia
by: Wasfi Fares, et al.
Published: (2016-01-01)

Iminosugars: promising therapeutics for influenza infection
by: Tyrrell, B, et al.
Published: (2016)

Absence of Crimean-Congo haemorrhagic fever virus in the tick Hyalomma aegyptium parasitizing the spur-thighed tortoise (Testudo graeca) in Tunisia
by: Fares Wasfi, et al.
Published: (2019-01-01)

Detection of Crimean Congo haemorrhagic fever virus in North-eastern Senegal, Bokidiawé 2019
by: Idrissa Dieng, et al.
Published: (2020-01-01)

Next generation sequencing of southern African Crimean-Congo haemorrhagic fever virus isolates
by: D. Goedhals, et al.
Published: (2014-04-01)

Presence of antibodies to Crimean Congo haemorrhagic fever virus in sheep in Tunisia, North Africa
by: Médiha Khamassi Khbou, et al.
Published: (2021-11-01)

Evaluation of the virucidal efficacy of commercial antiviral drugs against Lasota virus a surrogate for enveloped viruses
by: Amaal F. Ghanim, et al.
Published: (2018-12-01)

Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target
by: Sobala, Ł, et al.
Published: (2020)

Antagonistic antiviral activity between IFN-lambda and IFN-alpha against lethal Crimean-Congo hemorrhagic fever virus in vitro.
by: Licia Bordi, et al.
Published: (2015-01-01)

Molecular sequence analysis of Crimean-Congo haemorrhagic fever virus and the discovery and characterisation of novel sarbecoviruses
by: Crook, J
Published: (2024)

Crimean-Congo haemorrhagic fever virus in Hyalomma impeltatum ticks from North Kordofan, the Sudan
by: Lidia Chitimia-Dobler, et al.
Published: (2019-12-01)