The curious case of an internal pilot in a multicentre randomised trial-time for a rethink?
Multicentre randomised trials are complex projects with many operational uncertainties. The embedding of a formal check upon study progress and viability at a pre-specified time point (sometimes referred to as an 'internal pilot') is becoming increasingly common within multicentre pragmati...
| Main Authors: | , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
BioMed Central
2016
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| _version_ | 1826275094100443136 |
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| author | Cook, J Beard, D Cook, J MacLennan, G |
| author_facet | Cook, J Beard, D Cook, J MacLennan, G |
| author_sort | Cook, J |
| collection | OXFORD |
| description | Multicentre randomised trials are complex projects with many operational uncertainties. The embedding of a formal check upon study progress and viability at a pre-specified time point (sometimes referred to as an 'internal pilot') is becoming increasingly common within multicentre pragmatic randomised trials. However, it is worth considering this practice. We argue that most, if not all, multicentre trials have reassessment of the recruitment strategy and study processes whilst the study is running. Additionally, we propose discontinuation of the 'internal/external pilot study' terminology. Instead, we suggest for an alternative taxonomy along with greater recognition of the process of refinement which routinely occurs in trials and transparent reporting of it. |
| first_indexed | 2024-03-06T22:53:28Z |
| format | Journal article |
| id | oxford-uuid:5f94c567-a27d-415e-8e1f-4aecd3a5e47b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:53:28Z |
| publishDate | 2016 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:5f94c567-a27d-415e-8e1f-4aecd3a5e47b2022-03-26T17:47:50ZThe curious case of an internal pilot in a multicentre randomised trial-time for a rethink?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5f94c567-a27d-415e-8e1f-4aecd3a5e47bEnglishSymplectic Elements at OxfordBioMed Central2016Cook, JBeard, DCook, JMacLennan, GMulticentre randomised trials are complex projects with many operational uncertainties. The embedding of a formal check upon study progress and viability at a pre-specified time point (sometimes referred to as an 'internal pilot') is becoming increasingly common within multicentre pragmatic randomised trials. However, it is worth considering this practice. We argue that most, if not all, multicentre trials have reassessment of the recruitment strategy and study processes whilst the study is running. Additionally, we propose discontinuation of the 'internal/external pilot study' terminology. Instead, we suggest for an alternative taxonomy along with greater recognition of the process of refinement which routinely occurs in trials and transparent reporting of it. |
| spellingShingle | Cook, J Beard, D Cook, J MacLennan, G The curious case of an internal pilot in a multicentre randomised trial-time for a rethink? |
| title | The curious case of an internal pilot in a multicentre randomised trial-time for a rethink? |
| title_full | The curious case of an internal pilot in a multicentre randomised trial-time for a rethink? |
| title_fullStr | The curious case of an internal pilot in a multicentre randomised trial-time for a rethink? |
| title_full_unstemmed | The curious case of an internal pilot in a multicentre randomised trial-time for a rethink? |
| title_short | The curious case of an internal pilot in a multicentre randomised trial-time for a rethink? |
| title_sort | curious case of an internal pilot in a multicentre randomised trial time for a rethink |
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