The curious case of an internal pilot in a multicentre randomised trial-time for a rethink?

Multicentre randomised trials are complex projects with many operational uncertainties. The embedding of a formal check upon study progress and viability at a pre-specified time point (sometimes referred to as an 'internal pilot') is becoming increasingly common within multicentre pragmati...

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Váldodahkkit: Cook, J, Beard, D, MacLennan, G
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: BioMed Central 2016