Consensus statements on the utility of defining ARDS and the utility of past and current definitions of ARDS—protocol for a Delphi study
Introduction: Acute respiratory distress syndrome (ARDS), marked by acute hypoxemia and bilateral pulmonary infiltrates, has been defined in multiple ways since its first description. This Delphi study aims to collect global opinions on the conceptual framework of ARDS, assess the usefulness of comp...
| मुख्य लेखकों: | , , , , , , , |
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| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
BMJ Publishing Group
2024
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| _version_ | 1826313569510096896 |
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| author | Nasa, P Bos, LD Estenssoro, E van Haren, FM Serpa Neto, A Rocco, PR Slutsky, AS Schultz, MJ |
| author_facet | Nasa, P Bos, LD Estenssoro, E van Haren, FM Serpa Neto, A Rocco, PR Slutsky, AS Schultz, MJ |
| author_sort | Nasa, P |
| collection | OXFORD |
| description | Introduction: Acute respiratory distress syndrome (ARDS), marked by acute hypoxemia and bilateral pulmonary infiltrates, has been defined in multiple ways since its first description. This Delphi study aims to collect global opinions on the conceptual framework of ARDS, assess the usefulness of components within current and past definitions and investigate the role of subphenotyping. The varied expertise of the panel will provide valuable insights for refining future ARDS definitions and improving clinical management. Methods: A diverse panel of 35–40 experts will be selected based on predefined criteria. Multiple choice questions (MCQs) or 7-point Likert-scale statements will be used in the iterative Delphi rounds to achieve consensus on key aspects related to the utility of definitions and subphenotyping. The Delphi rounds will be continued until a stable agreement or disagreement is achieved for all statements. Analysis: Consensus will be considered as reached when a choice in MCQs or Likert-scale statement achieved ≥80% of votes for agreement or disagreement. The stability will be checked by non-parametric χ2 tests or Kruskal Wallis test starting from the second round of Delphi process. A p-value ≥0.05 will be used to define stability. Ethics and dissemination: The study will be conducted in full concordance with the principles of the Declaration of Helsinki and will be reported according to CREDES guidance. This study has been granted an ethical approval waiver by the NMC Healthcare Regional Research Ethics Committee, Dubai (NMCHC/CR/DXB/REC/APP/002), owing to the nature of the research. Informed consent will be obtained from all panellists before the start of the Delphi process. The study will be published in a peer-review journal with the authorship agreed as per ICMJE requirements. Trial registration number: NCT06159465. |
| first_indexed | 2024-09-25T04:15:25Z |
| format | Journal article |
| id | oxford-uuid:5f962078-4c84-45fc-a50d-88fb2ac9e859 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:15:25Z |
| publishDate | 2024 |
| publisher | BMJ Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:5f962078-4c84-45fc-a50d-88fb2ac9e8592024-07-20T14:49:24ZConsensus statements on the utility of defining ARDS and the utility of past and current definitions of ARDS—protocol for a Delphi studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5f962078-4c84-45fc-a50d-88fb2ac9e859EnglishJisc Publications RouterBMJ Publishing Group2024Nasa, PBos, LDEstenssoro, Evan Haren, FMSerpa Neto, ARocco, PRSlutsky, ASSchultz, MJIntroduction: Acute respiratory distress syndrome (ARDS), marked by acute hypoxemia and bilateral pulmonary infiltrates, has been defined in multiple ways since its first description. This Delphi study aims to collect global opinions on the conceptual framework of ARDS, assess the usefulness of components within current and past definitions and investigate the role of subphenotyping. The varied expertise of the panel will provide valuable insights for refining future ARDS definitions and improving clinical management. Methods: A diverse panel of 35–40 experts will be selected based on predefined criteria. Multiple choice questions (MCQs) or 7-point Likert-scale statements will be used in the iterative Delphi rounds to achieve consensus on key aspects related to the utility of definitions and subphenotyping. The Delphi rounds will be continued until a stable agreement or disagreement is achieved for all statements. Analysis: Consensus will be considered as reached when a choice in MCQs or Likert-scale statement achieved ≥80% of votes for agreement or disagreement. The stability will be checked by non-parametric χ2 tests or Kruskal Wallis test starting from the second round of Delphi process. A p-value ≥0.05 will be used to define stability. Ethics and dissemination: The study will be conducted in full concordance with the principles of the Declaration of Helsinki and will be reported according to CREDES guidance. This study has been granted an ethical approval waiver by the NMC Healthcare Regional Research Ethics Committee, Dubai (NMCHC/CR/DXB/REC/APP/002), owing to the nature of the research. Informed consent will be obtained from all panellists before the start of the Delphi process. The study will be published in a peer-review journal with the authorship agreed as per ICMJE requirements. Trial registration number: NCT06159465. |
| spellingShingle | Nasa, P Bos, LD Estenssoro, E van Haren, FM Serpa Neto, A Rocco, PR Slutsky, AS Schultz, MJ Consensus statements on the utility of defining ARDS and the utility of past and current definitions of ARDS—protocol for a Delphi study |
| title | Consensus statements on the utility of defining ARDS and the utility of past and current definitions of ARDS—protocol for a Delphi study |
| title_full | Consensus statements on the utility of defining ARDS and the utility of past and current definitions of ARDS—protocol for a Delphi study |
| title_fullStr | Consensus statements on the utility of defining ARDS and the utility of past and current definitions of ARDS—protocol for a Delphi study |
| title_full_unstemmed | Consensus statements on the utility of defining ARDS and the utility of past and current definitions of ARDS—protocol for a Delphi study |
| title_short | Consensus statements on the utility of defining ARDS and the utility of past and current definitions of ARDS—protocol for a Delphi study |
| title_sort | consensus statements on the utility of defining ards and the utility of past and current definitions of ards protocol for a delphi study |
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