Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs
Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA–mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the ro...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society of Chemistry
2018
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| _version_ | 1797071457101021184 |
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| author | Chan, K Peng, B Umar, M Chan, C Sahakyan, A Le, M Kwok, C |
| author_facet | Chan, K Peng, B Umar, M Chan, C Sahakyan, A Le, M Kwok, C |
| author_sort | Chan, K |
| collection | OXFORD |
| description | Here we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA–mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation. |
| first_indexed | 2024-03-06T22:53:31Z |
| format | Journal article |
| id | oxford-uuid:5f98cab1-d8e9-43fe-8457-4debc17d586e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:53:31Z |
| publishDate | 2018 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:5f98cab1-d8e9-43fe-8457-4debc17d586e2022-03-26T17:47:58ZStructural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5f98cab1-d8e9-43fe-8457-4debc17d586eEnglishSymplectic Elements at OxfordRoyal Society of Chemistry2018Chan, KPeng, BUmar, MChan, CSahakyan, ALe, MKwok, CHere we identify hundreds of RNA G-quadruplex (rG4) candidates in microRNAs (miRNAs), characterize the miRNA structure and miRNA–mRNA interactions on several mammalian-conserved miRNAs, and reveal the formation of rG4s in miRNAs. Notably, we study the effect of these rG4s in cells and uncover the role of rG4s in miRNA-mediated post-transcriptional regulation. |
| spellingShingle | Chan, K Peng, B Umar, M Chan, C Sahakyan, A Le, M Kwok, C Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs |
| title | Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs |
| title_full | Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs |
| title_fullStr | Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs |
| title_full_unstemmed | Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs |
| title_short | Structural analysis reveals the formation and role of RNA G-quadruplex structures in human mature microRNAs |
| title_sort | structural analysis reveals the formation and role of rna g quadruplex structures in human mature micrornas |
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