Sharp injury to articular cartilage activates JNK and NF kappa B and induces expression of inflammatory response genes

Geahča maid

• Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB.
  Dahkki: Alexander, S, et al.
  Almmustuhtton: (2007)
• Apolipoprotein A-1 is a novel inducer of aggrecan breakdown in cultured articular cartilage
  Dahkki: Didangelos, A, et al.
  Almmustuhtton: (2009)
• Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis.
  Dahkki: Saklatvala, J
  Almmustuhtton: (2007)
• Activin is an anti-catabolic cytokine produced by injured cartilage via release of fibroblast growth factor-2 and activation of nuclear factor kappa B
  Dahkki: Watt, F, et al.
  Almmustuhtton: (2008)
• Src and fibroblast growth factor 2 independently regulate signaling and gene expression induced by experimental injury to intact articular cartilage.
  Dahkki: Watt, F, et al.
  Almmustuhtton: (2012)