Glucose tolerance in rural diabetic Thais, first-degree relatives and non-diabetic controls.
To determine whether non-insulin-dependent diabetes mellitus (NIDDM) in a rural Thai population is characterised by insulin resistance and hyperinsulinaemia, 17 unselected diabetic outpatients from a regional hospital, five first-degree relatives and 10 healthy controls were studied. Subjects in the...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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1995
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| _version_ | 1797071465570369536 |
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| author | Davis, T Pramukkul, P Suputtamongkol, Y Chaowagul, W Levy, J |
| author_facet | Davis, T Pramukkul, P Suputtamongkol, Y Chaowagul, W Levy, J |
| author_sort | Davis, T |
| collection | OXFORD |
| description | To determine whether non-insulin-dependent diabetes mellitus (NIDDM) in a rural Thai population is characterised by insulin resistance and hyperinsulinaemia, 17 unselected diabetic outpatients from a regional hospital, five first-degree relatives and 10 healthy controls were studied. Subjects in these groups were matched as closely as possible for age and sex, and mean body mass indices were similar (mean +/- S.D.; 21.8 +/- 5.5, 20.6 +/- 1.4 and 21.8 +/- 2.3 kg/m2, respectively, P > 0.5). Beta-cell function (%B) and insulin sensitivity (%S), expressed relative to values for non-diabetic Caucasians, were assessed mathematically using the 'CIGMA' model and plasma glucose and insulin achieved after a standard 1-h glucose infusion. The diabetic patients had higher fasting plasma glucose concentrations than the controls (8.6 +/- 4.0 vs. 4.6 +/- 0.4 mmol/l, P < 0.01) but plasma insulin levels were comparable (geometric mean [-S.D.-+S.D.]; 4.0 [1.7-9.4] vs. 4.0 [1.7-9.2] mU/l, P > 0.1). %B in the diabetic group (21% [10-41]) was lower than in the controls (128% [88-187], P < 0.001) while %S tended to be higher (185% [86-400] vs. 111% [49-251], 0.1 > P > 0.05). Relatives had intermediate values of both variables. %S and %B correlated poorly in the diabetic group (P > 0.1) but together accounted for 90% of the variation in basal plasma glucose (multiple r = 0.95, n = 17, P < 0.0001). Beta-cell dysfunction appears the primary defect in diabetic patients from a Thai subsistence farming population. Insulin resistance may not always characterise NIDDM in geographical areas where a 'thrifty genotype' would be expected; other factors associated with diabetes in developing countries (such increased susceptibility to serious infections) may also influence diabetes prevalence. |
| first_indexed | 2024-03-06T22:53:39Z |
| format | Journal article |
| id | oxford-uuid:5fa4e6d4-1e19-4e94-b238-5348f8a42279 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:53:39Z |
| publishDate | 1995 |
| record_format | dspace |
| spelling | oxford-uuid:5fa4e6d4-1e19-4e94-b238-5348f8a422792022-03-26T17:48:13ZGlucose tolerance in rural diabetic Thais, first-degree relatives and non-diabetic controls.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5fa4e6d4-1e19-4e94-b238-5348f8a42279EnglishSymplectic Elements at Oxford1995Davis, TPramukkul, PSuputtamongkol, YChaowagul, WLevy, JTo determine whether non-insulin-dependent diabetes mellitus (NIDDM) in a rural Thai population is characterised by insulin resistance and hyperinsulinaemia, 17 unselected diabetic outpatients from a regional hospital, five first-degree relatives and 10 healthy controls were studied. Subjects in these groups were matched as closely as possible for age and sex, and mean body mass indices were similar (mean +/- S.D.; 21.8 +/- 5.5, 20.6 +/- 1.4 and 21.8 +/- 2.3 kg/m2, respectively, P > 0.5). Beta-cell function (%B) and insulin sensitivity (%S), expressed relative to values for non-diabetic Caucasians, were assessed mathematically using the 'CIGMA' model and plasma glucose and insulin achieved after a standard 1-h glucose infusion. The diabetic patients had higher fasting plasma glucose concentrations than the controls (8.6 +/- 4.0 vs. 4.6 +/- 0.4 mmol/l, P < 0.01) but plasma insulin levels were comparable (geometric mean [-S.D.-+S.D.]; 4.0 [1.7-9.4] vs. 4.0 [1.7-9.2] mU/l, P > 0.1). %B in the diabetic group (21% [10-41]) was lower than in the controls (128% [88-187], P < 0.001) while %S tended to be higher (185% [86-400] vs. 111% [49-251], 0.1 > P > 0.05). Relatives had intermediate values of both variables. %S and %B correlated poorly in the diabetic group (P > 0.1) but together accounted for 90% of the variation in basal plasma glucose (multiple r = 0.95, n = 17, P < 0.0001). Beta-cell dysfunction appears the primary defect in diabetic patients from a Thai subsistence farming population. Insulin resistance may not always characterise NIDDM in geographical areas where a 'thrifty genotype' would be expected; other factors associated with diabetes in developing countries (such increased susceptibility to serious infections) may also influence diabetes prevalence. |
| spellingShingle | Davis, T Pramukkul, P Suputtamongkol, Y Chaowagul, W Levy, J Glucose tolerance in rural diabetic Thais, first-degree relatives and non-diabetic controls. |
| title | Glucose tolerance in rural diabetic Thais, first-degree relatives and non-diabetic controls. |
| title_full | Glucose tolerance in rural diabetic Thais, first-degree relatives and non-diabetic controls. |
| title_fullStr | Glucose tolerance in rural diabetic Thais, first-degree relatives and non-diabetic controls. |
| title_full_unstemmed | Glucose tolerance in rural diabetic Thais, first-degree relatives and non-diabetic controls. |
| title_short | Glucose tolerance in rural diabetic Thais, first-degree relatives and non-diabetic controls. |
| title_sort | glucose tolerance in rural diabetic thais first degree relatives and non diabetic controls |
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