Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.

The oxygen-dependent hydroxylation of proline residues in the alpha subunit of hypoxia-inducible transcription factor (HIFalpha) is central to the hypoxic response in animals. Prolyl hydroxylation of HIFalpha increases its binding to the von Hippel-Lindau protein (pVHL), so signaling for degradation...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Chowdhury, R, McDonough, M, Mecinović, J, Loenarz, C, Flashman, E, Hewitson, K, Domene, C, Schofield, C
Format: Journal article
Sprache:English
Veröffentlicht: 2009