Severity of COVID-19 in patients with diarrhoea: a systematic review and meta-analysis
COVID-19 patients occasionally present with diarrhoea. Our objective was to estimate the risk of developing the severe disease in COVID-19 patients with and without diarrhoea and to provide a more precise estimate of the prevalence of COVID-19-associated digestive symptoms. A total of 88 studies (n...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
MDPI
2023
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| _version_ | 1797111278072758272 |
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| author | Dhakal, S Charoen, P Pan-ngum, W Luvira, V Sivakorn, C Hanboonkunupakarn, B Chirapongsathorn, S Poovorawan, K |
| author_facet | Dhakal, S Charoen, P Pan-ngum, W Luvira, V Sivakorn, C Hanboonkunupakarn, B Chirapongsathorn, S Poovorawan, K |
| author_sort | Dhakal, S |
| collection | OXFORD |
| description | COVID-19 patients occasionally present with diarrhoea. Our objective was to estimate the risk of developing the severe disease in COVID-19 patients with and without diarrhoea and to provide a more precise estimate of the prevalence of COVID-19-associated digestive symptoms. A total of 88 studies (n = 67,794) on patients with a COVID-19 infection published between 1 January 2020 and 20 October 2022 were included in this meta-analysis. The overall prevalence of digestive symptoms was 27% (95% confidence interval (CI): 21–34%; I2 = 99%). According to our data, the pooled prevalence of diarrhoea symptoms in the 88 studies analysed was 17% (95% CI: 14–20%; I2 = 98%). The pooled estimate of nausea or vomiting in a total of 60 studies was 12% (95% CI: 8–15%; I2 = 98%). We also analysed 23 studies with eligible individuals (n = 3800) to assess the association between the disease severity and diarrhoea. Individuals who had diarrhoea were more likely to have experienced severe COVID-19 (odds ratio: 1.71; 95% CI: 1.31–2.24; p < 0.0001; I2 = 10%). Gastrointestinal symptoms and diarrhoea are frequently presenting COVID-19 manifestations that physicians should be aware of. |
| first_indexed | 2024-03-07T08:08:05Z |
| format | Journal article |
| id | oxford-uuid:5fb8c95a-342d-426e-bcd5-ae64072ec2d0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:08:05Z |
| publishDate | 2023 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:5fb8c95a-342d-426e-bcd5-ae64072ec2d02023-11-09T13:28:27ZSeverity of COVID-19 in patients with diarrhoea: a systematic review and meta-analysisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5fb8c95a-342d-426e-bcd5-ae64072ec2d0EnglishSymplectic ElementsMDPI2023Dhakal, SCharoen, PPan-ngum, WLuvira, VSivakorn, CHanboonkunupakarn, BChirapongsathorn, SPoovorawan, KCOVID-19 patients occasionally present with diarrhoea. Our objective was to estimate the risk of developing the severe disease in COVID-19 patients with and without diarrhoea and to provide a more precise estimate of the prevalence of COVID-19-associated digestive symptoms. A total of 88 studies (n = 67,794) on patients with a COVID-19 infection published between 1 January 2020 and 20 October 2022 were included in this meta-analysis. The overall prevalence of digestive symptoms was 27% (95% confidence interval (CI): 21–34%; I2 = 99%). According to our data, the pooled prevalence of diarrhoea symptoms in the 88 studies analysed was 17% (95% CI: 14–20%; I2 = 98%). The pooled estimate of nausea or vomiting in a total of 60 studies was 12% (95% CI: 8–15%; I2 = 98%). We also analysed 23 studies with eligible individuals (n = 3800) to assess the association between the disease severity and diarrhoea. Individuals who had diarrhoea were more likely to have experienced severe COVID-19 (odds ratio: 1.71; 95% CI: 1.31–2.24; p < 0.0001; I2 = 10%). Gastrointestinal symptoms and diarrhoea are frequently presenting COVID-19 manifestations that physicians should be aware of. |
| spellingShingle | Dhakal, S Charoen, P Pan-ngum, W Luvira, V Sivakorn, C Hanboonkunupakarn, B Chirapongsathorn, S Poovorawan, K Severity of COVID-19 in patients with diarrhoea: a systematic review and meta-analysis |
| title | Severity of COVID-19 in patients with diarrhoea: a systematic review and meta-analysis |
| title_full | Severity of COVID-19 in patients with diarrhoea: a systematic review and meta-analysis |
| title_fullStr | Severity of COVID-19 in patients with diarrhoea: a systematic review and meta-analysis |
| title_full_unstemmed | Severity of COVID-19 in patients with diarrhoea: a systematic review and meta-analysis |
| title_short | Severity of COVID-19 in patients with diarrhoea: a systematic review and meta-analysis |
| title_sort | severity of covid 19 in patients with diarrhoea a systematic review and meta analysis |
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