Transgene-encoded human CD2 acts in a dominant negative fashion to modify thymocyte selection signals in mice.

Transgene-encoded human CD2 acts in a dominant negative fashion to modify thymocyte selection signals in mice.

CD2 is a cell surface glycoprotein present on all T cells which has been shown to function as an adhesion and signaling molecule. Expressed early in T cell development, human CD2 (HCD2) has been suggested to play a role during thymopoiesis. However, the relevance of CD2 in T cell development has bee...

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Bibliographic Details
Main Authors: Melton, E, Sarner, N, Torkar, M, Van Der Merwe, P, Russell, J, Budd, R, Mamalaki, C, Tolaini, M, Kioussis, D, Zamoyska, R
Format: Journal article
Language:English
Published: 1996

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