The androgen receptor exon 1 trinucleotide repeat does not act as a modifier of the age of presentation in breast cancer.
The CAG repeat in exon 1 of the androgen receptor (AR) genes has been postulated as both a susceptibility allele and phenotypic modifier in BRCA1-associated breast cancers. We have analysed this repeat in a set of 178 breast cancer cases who have been selected only for age of presentation at 65 year...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2000
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| _version_ | 1826275138440527872 |
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| author | Given, H Radbourne, R Oag, H Merritt, S Barclay, E Hanby, A Lamlum, H McGrath, J Curran, C Tomlinson, I |
| author_facet | Given, H Radbourne, R Oag, H Merritt, S Barclay, E Hanby, A Lamlum, H McGrath, J Curran, C Tomlinson, I |
| author_sort | Given, H |
| collection | OXFORD |
| description | The CAG repeat in exon 1 of the androgen receptor (AR) genes has been postulated as both a susceptibility allele and phenotypic modifier in BRCA1-associated breast cancers. We have analysed this repeat in a set of 178 breast cancer cases who have been selected only for age of presentation at 65 years or less. No effect of repeat length on age of presentation was found and there was no association between repeat length and family history. In combination with the data from other workers, our findings suggest that the androgen receptor repeat does not act as a modifier gene or susceptibility locus outside the context of the hereditary breast/ovarian cancer syndrome. |
| first_indexed | 2024-03-06T22:54:08Z |
| format | Journal article |
| id | oxford-uuid:5fcb4e54-f097-4c2c-a99f-7daef5e598c5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:54:08Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:5fcb4e54-f097-4c2c-a99f-7daef5e598c52022-03-26T17:49:17ZThe androgen receptor exon 1 trinucleotide repeat does not act as a modifier of the age of presentation in breast cancer.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5fcb4e54-f097-4c2c-a99f-7daef5e598c5EnglishSymplectic Elements at Oxford2000Given, HRadbourne, ROag, HMerritt, SBarclay, EHanby, ALamlum, HMcGrath, JCurran, CTomlinson, IThe CAG repeat in exon 1 of the androgen receptor (AR) genes has been postulated as both a susceptibility allele and phenotypic modifier in BRCA1-associated breast cancers. We have analysed this repeat in a set of 178 breast cancer cases who have been selected only for age of presentation at 65 years or less. No effect of repeat length on age of presentation was found and there was no association between repeat length and family history. In combination with the data from other workers, our findings suggest that the androgen receptor repeat does not act as a modifier gene or susceptibility locus outside the context of the hereditary breast/ovarian cancer syndrome. |
| spellingShingle | Given, H Radbourne, R Oag, H Merritt, S Barclay, E Hanby, A Lamlum, H McGrath, J Curran, C Tomlinson, I The androgen receptor exon 1 trinucleotide repeat does not act as a modifier of the age of presentation in breast cancer. |
| title | The androgen receptor exon 1 trinucleotide repeat does not act as a modifier of the age of presentation in breast cancer. |
| title_full | The androgen receptor exon 1 trinucleotide repeat does not act as a modifier of the age of presentation in breast cancer. |
| title_fullStr | The androgen receptor exon 1 trinucleotide repeat does not act as a modifier of the age of presentation in breast cancer. |
| title_full_unstemmed | The androgen receptor exon 1 trinucleotide repeat does not act as a modifier of the age of presentation in breast cancer. |
| title_short | The androgen receptor exon 1 trinucleotide repeat does not act as a modifier of the age of presentation in breast cancer. |
| title_sort | androgen receptor exon 1 trinucleotide repeat does not act as a modifier of the age of presentation in breast cancer |
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