A mathematical framework for the emergence of winners and losers in cell competition
Cell competition is a process in multicellular organisms where cells interact with their neighbours to determine a "winner" or "loser" status. The loser cells are eliminated through programmed cell death, leaving only the winner cells to populate the tissue. Cell competition is c...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2023
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| _version_ | 1826312855798939648 |
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| author | Pak, TF Pitt-Francis, J Baker, RE |
| author_facet | Pak, TF Pitt-Francis, J Baker, RE |
| author_sort | Pak, TF |
| collection | OXFORD |
| description | Cell competition is a process in multicellular organisms where cells interact with their neighbours to determine a "winner" or "loser" status. The loser cells are eliminated through programmed cell death, leaving only the winner cells to populate the tissue. Cell competition is context-dependent; the same cell type can win or lose depending on the cell type it is competing against. Hence, winner/loser status is an emergent property. A key question in cell competition is: how do cells acquire their winner/loser status? In this paper, we propose a mathematical framework for studying the emergence of winner/loser status based on a set of quantitative criteria that distinguishes competitive from non-competitive outcomes. We apply this framework in a cell-based modelling context, to both highlight the crucial role of active cell death in cell competition and identify the factors that drive cell competition. |
| first_indexed | 2024-04-09T03:56:00Z |
| format | Journal article |
| id | oxford-uuid:5fd00cba-9284-4675-bc0e-329b5d3b5b2a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:03:29Z |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:5fd00cba-9284-4675-bc0e-329b5d3b5b2a2024-05-08T12:21:07ZA mathematical framework for the emergence of winners and losers in cell competitionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5fd00cba-9284-4675-bc0e-329b5d3b5b2aEnglishSymplectic ElementsElsevier2023Pak, TFPitt-Francis, JBaker, RECell competition is a process in multicellular organisms where cells interact with their neighbours to determine a "winner" or "loser" status. The loser cells are eliminated through programmed cell death, leaving only the winner cells to populate the tissue. Cell competition is context-dependent; the same cell type can win or lose depending on the cell type it is competing against. Hence, winner/loser status is an emergent property. A key question in cell competition is: how do cells acquire their winner/loser status? In this paper, we propose a mathematical framework for studying the emergence of winner/loser status based on a set of quantitative criteria that distinguishes competitive from non-competitive outcomes. We apply this framework in a cell-based modelling context, to both highlight the crucial role of active cell death in cell competition and identify the factors that drive cell competition. |
| spellingShingle | Pak, TF Pitt-Francis, J Baker, RE A mathematical framework for the emergence of winners and losers in cell competition |
| title | A mathematical framework for the emergence of winners and losers in cell competition |
| title_full | A mathematical framework for the emergence of winners and losers in cell competition |
| title_fullStr | A mathematical framework for the emergence of winners and losers in cell competition |
| title_full_unstemmed | A mathematical framework for the emergence of winners and losers in cell competition |
| title_short | A mathematical framework for the emergence of winners and losers in cell competition |
| title_sort | mathematical framework for the emergence of winners and losers in cell competition |
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