Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication

Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication

Somatic and germline mutations in the proofreading domain of the replicative DNA polymerase ε (POLE-exonuclease domain mutations, POLE-EDMs) are frequently found in colorectal and endometrial cancers and, occasionally, in other tumours. POLE-associated cancers typically display hypermutation, and a...

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Detalles Bibliográficos
Autores principales: Soriano, I, Vazquez, E, De Leon, N, Bertrand, S, Heitzer, E, Toumazou, S, Bo, Z, Palles, C, Pai, C-C, Humphrey, TC, Tomlinson, I, Cotterill, S, Kearsey, SE
Formato: Journal article
Lenguaje:English
Publicado: Public Library of Science 2021

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