Detection and characterization of HIV-1 specific T cell responses amongst exposed and unexposed HIV-1 seronegative individuals

Detection and characterization of HIV-1 specific T cell responses amongst exposed and unexposed HIV-1 seronegative individuals

<p>The primary aim of this thesis was to examine whether HIV-1 specific T cell responses in HIV-1 exposed seronegative (HESN) subjects could be firstly detected and if so, conferred protection against productive infection from HIV-1.</p> <p>Cultured IFN-γ ELISpot found 38.7-60% of...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Campion, S
Awduron Eraill:	McMichael, A
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2012
Pynciau:	Immunology Tropical medicine Medical sciences HIV/AIDS

Eitemau Tebyg

Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals.
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T cell responses in Kenyan infants: impact on HIV-1 evolution during infection and an assessment of vaccine-induced memory responses in HIV-exposed uninfected infants
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TCF-1 regulates HIV-specific CD8+ T cell expansion capacity
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Definition of the early HIV-1 signalosome in dendritic cells
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Anti-HIV antibody development up to 1 year after antiretroviral therapy initiation in acute HIV infection
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Assessment of HIV-1 integration in tissues and subsets across infection stages
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HLA-B51 associated HIV-1 viral control
gan: Peng, Y
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Characterisation of T cells induced by candidate conserved region HIV-1 vaccines in healthy HIV-1/2 negative volunteers
gan: Ahmed, T, et al.
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HIV-specific interleukin-10 responses and immune modulation
gan: Clutton, G
Cyhoeddwyd: (2012)

The latency-reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific T cells
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Cyhoeddwyd: (2023-09-01)

HIV-specific T cell responses reflect substantive in vivo interactions with antigen despite long-term therapy
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IL-15 enhances HIV-1 infection by promoting survival and proliferation of CCR5+CD4+ T cells
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HIV-1 induction of macrophage immune mediators
gan: Dacon, C
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The impact of HIV-1 disease and its treatment on mycobacterium tuberculosis-specific immunity
gan: Murray, L
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Reduced anti-viral IgG repertoire in HIV-exposed but uninfected infants compared to HIV-unexposed infants
gan: Rachael Gachogo, et al.
Cyhoeddwyd: (2024-07-01)

A functional and structural study of HLA-B*2705 restricted CTL responses associated with delayed HIV-1 disease progression
gan: Pymm, PG
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Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype
gan: Vinicius Vieira, et al.
Cyhoeddwyd: (2023-02-01)

Distinct patterns of natural selection in the reverse transcriptase gene of HIV-1 in the presence and absence of antiretroviral therapy
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Population-specific HLA impact in immune control of HIV in Mexico and non-Mexican HIV infected cohorts
gan: Juarez Molina, CI
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The TLR7/IRF-5 axis sensitizes memory CD4+ T cells to Fas-mediated apoptosis during HIV-1 infection
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Higher circulating intermediate monocytes are associated with cognitive function in women with HIV
gan: Rebecca T. Veenhuis, et al.
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Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells
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Inefficient cytotoxic T lymphocyte-mediated killing of HIV-1-infected cells in vivo
gan: Asquith, B, et al.
Cyhoeddwyd: (2006)

Immunodominant CD8+ T cell responses to HIV-1 infection - 'The good and the bad'
gan: Culshaw, A
Cyhoeddwyd: (2011)

Characterisation of the HIV-1 reservoir and the potential for viral eradication
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Natural and therapy-induced immune control of HIV-1
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Distinct mucosal and systemic immunological characteristics in transgender women potentially relating to HIV acquisition
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Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control
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The role of Nef protein in the pathogenesis of HIV infection
gan: Rajapaksa, U
Cyhoeddwyd: (2013)

Identification of immunological targets for HIV-1 vaccine and cure strategies
gan: Hancock, G
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Imaging of HIV-1 spread from T cells and Macrophages to Astrocytes
gan: Do, T
Cyhoeddwyd: (2014)

The impact of host and therapy mediated selection on HIV-1 evolution
gan: Huang, K
Cyhoeddwyd: (2010)

The design and development of an HIV-1 vaccine to elicit a broadly neutralising antibody response
gan: Wan, L, et al.
Cyhoeddwyd: (2012)

Killer immunoglobulin-like receptor polymorphism in a Chinese HIV-1 infection cohort
gan: Wang, L
Cyhoeddwyd: (2014)

Decay kinetics of HIV-1 specific T-cell responses in vertically HIV-1 exposed seronegative (HESN) infants
gan: Sara J Holditch, et al.
Cyhoeddwyd: (2012-01-01)

A study of the phenotype and function of HLA-C restricted CD8 T cells in HIV-1 infection
gan: Corrah, TW
Cyhoeddwyd: (2011)

Enhanced Signaling Through the TLR9 Pathway Is Associated With Resistance to HIV-1 Infection in Chinese HIV-1–Exposed Seronegative Individuals
gan: Junjun Jiang, et al.
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Feeding practices and nutritional status of HIV-exposed and HIV-unexposed infants in the Western Cape
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Cyhoeddwyd: (2016-05-01)

The innate immune effector cell response against HIV-1
gan: Smalls-Mantey, A
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Age-specific associations with dental caries in HIV-infected, exposed but uninfected and HIV-unexposed uninfected children in Nigeria
gan: Paul Akhigbe, et al.
Cyhoeddwyd: (2022-09-01)