USP16 is an ISG15 cross-reactive deubiquitinase targeting a subset of metabolic pathway-related proteins

USP16 is an ISG15 cross-reactive deubiquitinase targeting a subset of metabolic pathway-related proteins

The ubiquitin-like modifier ISG15 can modulate host and viral proteins to restrict viral and microbial infections, and act as a cytokine. Its expression and conjugation are strongly up-regulated by type I interferons. Here we identify the deubiquitinating enzyme USP16 as an ISG15 cross-reactive prot...

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Bibliografiska uppgifter
Huvudupphovsmän: Gan, J, Pinto-Fernandez, A, Flierman, D, Akkermans, JJLL, O'Brien, DP, Greenwood, H, Scott, HC, Neefjes, J, Fritz, G, Knobeloch, K-P, van Dam, H, Kessler, BM, Ovaa, H, Geurink, PP, Sapmaz, A
Materialtyp: Internet publication
Språk:English
Publicerad: 2023

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