A high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression.

A high-frequency polymorphism in exon 6 of the CD45 tyrosine phosphatase gene (PTPRC) resulting in altered isoform expression.

CD45 (leukocyte common) antigen is a hemopoietic cell-specific tyrosine phosphatase essential for antigen receptor-mediated signaling in lymphocytes. The molecule undergoes complex alternative splicing in the extracellular domain, and different patterns of CD45 splicing are associated with distinct...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Stanton, T, Boxall, S, Hirai, K, Dawes, R, Tonks, S, Yasui, T, Kanaoka, Y, Yuldasheva, N, Ishiko, O, Bodmer, W, Beverley, P, Tchilian, E
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2003

Antzeko izenburuak

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The exon A (C77G) mutation is a common cause of abnormal CD45 splicing in humans.
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A CD45 polymorphism associated with abnormal splicing is absent in African populations
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