Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

Genome-wide association meta-analyses and fine-mapping elucidate pathways influencing albuminuria.

Increased levels of the urinary albumin-to-creatinine ratio (UACR) are associated with higher risk of kidney disease progression and cardiovascular events, but underlying mechanisms are incompletely understood. Here, we conduct trans-ethnic (n = 564,257) and European-ancestry specific meta-analyses...

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Autors principals: Teumer, A, Li, Y, Ghasemi, S, Prins, BP, Wuttke, M, Hermle, T, Giri, A, Sieber, KB, Qiu, C, Kirsten, H, Tin, A, Chu, AY, Bansal, N, Feitosa, MF, Wang, L, Chai, J-F, Cocca, M, Fuchsberger, C, Gorski, M, Hoppmann, A, Horn, K, Li, M, Marten, J, Noce, D, Nutile, T, Sedaghat, S, Sveinbjornsson, G, Tayo, BO, van der Most, PJ, Xu, Y, Yu, Z, Gerstner, L, Ärnlöv, J, Bakker, SJL, Baptista, D, Biggs, ML, Boerwinkle, E, Brenner, H, Burkhardt, R, Carroll, RJ, Chee, M-L, Chen, M, Cheng, C-Y, Cook, JP, Coresh, J, Corre, T, Danesh, J, de Borst, MH, De Grandi, A, Lindgren, CM
Format: Journal article
Idioma:English
Publicat: Nature Research 2019

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