HIV envelope gp120 activates LFA-1 on CD4 T-lymphocytes and increases cell susceptibility to LFA-1-targeting leukotoxin (LtxA)

The cellular adhesion molecule LFA-1 and its ICAM-1 ligand play an important role in promoting HIV-1 infectivity and transmission. These molecules are present on the envelope of HIV-1 virions and are integral components of the HIV virological synapse. However, cellular activation is required to conv...

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Main Authors: Hioe, C, Tuen, M, Vasiliver-Shamis, G, Alvarez, Y, Prins, K, Banerjee, S, Nádas, A, Cho, M, Dustin, M, Kachlany, S
格式: Journal article
语言:English
出版: Public Library of Science 2011