Binocular facilitation in light-mediated melatonin suppression?
In humans, the production of melatonin is suppressed by light exposure. This effect is mediated by a retinal pathway involving the melanopsin-containing intrinsincally photosensitive retinal ganglion cells (ipRGCs), which exhibit maximum sensitivity to short-wavelength light. Here, based on extant a...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Wiley
2019
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| _version_ | 1826275217804099584 |
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| author | Spitschan, M Cajochen, C |
| author_facet | Spitschan, M Cajochen, C |
| author_sort | Spitschan, M |
| collection | OXFORD |
| description | In humans, the production of melatonin is suppressed by light exposure. This effect is mediated by a retinal pathway involving the melanopsin-containing intrinsincally photosensitive retinal ganglion cells (ipRGCs), which exhibit maximum sensitivity to short-wavelength light. Here, based on extant and published data, we examine how signals from the two eyes are integrated in driving the suppression of melatonin by light. We find that melatonin suppression by light exposure to two eyes corresponds to a sensitivity shift by about 1.2 log units (factor ~17.4). |
| first_indexed | 2024-03-06T22:55:21Z |
| format | Journal article |
| id | oxford-uuid:602d62bc-40aa-4c77-9454-b713813eaa35 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:55:21Z |
| publishDate | 2019 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:602d62bc-40aa-4c77-9454-b713813eaa352022-03-26T17:51:47ZBinocular facilitation in light-mediated melatonin suppression?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:602d62bc-40aa-4c77-9454-b713813eaa35EnglishSymplectic Elements at OxfordWiley2019Spitschan, MCajochen, CIn humans, the production of melatonin is suppressed by light exposure. This effect is mediated by a retinal pathway involving the melanopsin-containing intrinsincally photosensitive retinal ganglion cells (ipRGCs), which exhibit maximum sensitivity to short-wavelength light. Here, based on extant and published data, we examine how signals from the two eyes are integrated in driving the suppression of melatonin by light. We find that melatonin suppression by light exposure to two eyes corresponds to a sensitivity shift by about 1.2 log units (factor ~17.4). |
| spellingShingle | Spitschan, M Cajochen, C Binocular facilitation in light-mediated melatonin suppression? |
| title | Binocular facilitation in light-mediated melatonin suppression? |
| title_full | Binocular facilitation in light-mediated melatonin suppression? |
| title_fullStr | Binocular facilitation in light-mediated melatonin suppression? |
| title_full_unstemmed | Binocular facilitation in light-mediated melatonin suppression? |
| title_short | Binocular facilitation in light-mediated melatonin suppression? |
| title_sort | binocular facilitation in light mediated melatonin suppression |
| work_keys_str_mv | AT spitschanm binocularfacilitationinlightmediatedmelatoninsuppression AT cajochenc binocularfacilitationinlightmediatedmelatoninsuppression |