Asymmetric synthesis of nortropanes via Rh-catalyzed allylic arylation

Tropane derivatives are extensively used in medicine, but catalytic asymmetric methods for their synthesis are underexplored. Here we report Rh-catalyzed asymmetric Suzuki-Miyaura type cross-coupling reactions between a racemic N-Bocnortropane-derived allylic chloride and (hetero-)aryl-boronic ester...

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Hlavní autoři: Zhang, Y, Goetzke, F, Christensen, K, Fletcher, SP
Médium: Journal article
Jazyk:English
Vydáno: American Chemical Society 2022