Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits

Genomewide meta‐analysis identifies loci associated with IGF‐I and IGFBP‐3 levels with impact on age‐related traits

The growth hormone/insulin‐like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF‐related proteins including IGF‐I and IGF‐binding protein‐3 (IGFBP‐3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer....

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Main Authors: Teumer, A, Qi, Q, Nethander, M, Aschard, H, Bandinelli, S, Beekman, M, Berndt, SI, Bidlingmaier, M, Broer, L, Charge Longevity Working Group, Cappola, A, Ceda, GP, Chanock, S, Chen, M-H, Chen, TC, Chen, Y-DI, Chung, J, Del Greco Miglianico, F, Eriksson, J, Ferrucci, L, Friedrich, N, Gnewuch, C, Goodarzi, MO, Grarup, N, Guo, T, Hammer, E, Hayes, RB, Hicks, AA, Hofman, A, Houwing-Duistermaat, JJ, Hu, F, Hunter, DJ, Husemoen, LL, Isaacs, A, Jacobs, KB, Janssen, JAMJL, Jansson, J-O, Jehmlich, N, Johnson, S, Juul, A, Karlsson, M, Kilpelainen, TO, Kovacs, P, Kraft, P, Li, C, Linneberg, A, Liu, Y, Loos, RJF, Body Composition Genetics Consortium, Lorentzon, M, Lu, Y, Maggio, M, Magi, R, Meigs, J, Mellström, D, Nauck, M, Newman, AB, Pollak, MN, Pramstaller, PP, Prokopenko, I, Psaty, BM, Reincke, M, Rimm, EB, Rotter, JI, Pierre, A, Schurmann, C, Seshadri, S, Sjögren, K, Slagboom, PE, Strickler, HD, Stumvoll, M, Suh, Y, Sun, Q, Zhang, C, Svensson, J, Tanaka, T, Tare, A, Tönjes, A, Uh, H-W, Van Duijn, CM, Van Heemst, D, Vandenput, L, Vasan, RS, Völker, U, Willems, SM, Ohlsson, C, Wallaschofski, H, Kaplan, RC
Format: Journal article
Language:English
Published: Wiley 2016

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