IRF5 is required for late-phase TNF secretion by human dendritic cells.

IRF5 is required for late-phase TNF secretion by human dendritic cells.

Spatially and temporally controlled expression of inflammatory mediators is critical for an appropriate immune response. In this study, we define the role for interferon regulatory factor 5 (IRF5) in secretion of tumor necrosis factor (TNF) by human dendritic cells (DCs). We demonstrate that DCs but...

Descrizione completa

Dettagli Bibliografici
Autori principali:	Krausgruber, T, Saliba, D, Ryzhakov, G, Lanfrancotti, A, Blazek, K, Udalova, I
Natura:	Journal article
Lingua:	English
Pubblicazione:	2010

Documenti analoghi

KAP1/TRIM28: an inhibitor of IRF5 function in inflammatory macrophages
di: Eames, H, et al.
Pubblicazione: (2012)

Novel role of IRF5 in transcriptional inhibition of human IL-10 gene expression
di: Krausgruber, T, et al.
Pubblicazione: (2011)

IRF5 as a defining factor of M1 macrophage polarization
di: Krausgruber, T, et al.
Pubblicazione: (2010)

IRF5 PROMOTES INFLAMMATORY MACROPHAGE POLARIZATION AND TH1/TH17 RESPONSE
di: Krausgruber, T, et al.
Pubblicazione: (2011)

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses.
di: Krausgruber, T, et al.
Pubblicazione: (2011)

IRF5 interactome: search for novel therapeutic targets
di: Eames, H, et al.
Pubblicazione: (2010)

Interferon-β Production via Dectin-1-Syk-IRF5 Signaling in Dendritic Cells Is Crucial for Immunity to C.albicans
di: delFresno, C, et al.
Pubblicazione: (2013)

Interferon-β production via Dectin-1-Syk-IRF5 signaling in dendritic cells is crucial for immunity to C. albicans.
di: del Fresno, C, et al.
Pubblicazione: (2013)

IRF5 is a specific marker of inflammatory macrophages in vivo.
di: Weiss, M, et al.
Pubblicazione: (2013)

IRF5 Is a Specific Marker of Inflammatory Macrophages In Vivo
di: Miriam Weiss, et al.
Pubblicazione: (2013-01-01)

IRF5 controls macrophage-neutrophil axis in inflammation
di: Udalova, I
Pubblicazione: (2014)

IRF5:RelA interaction targets inflammatory genes in macrophages.
di: Saliba, D, et al.
Pubblicazione: (2014)

FOXO3 as a new IKK-ε-controlled check-point of regulation of IFN-β expression.
di: Luron, L, et al.
Pubblicazione: (2012)

A critical role for IRF5 in regulating allergic airway inflammation
di: Byrne, A, et al.
Pubblicazione: (2016)

Beyond the enhanceosome: cluster of novel κB sites downstream of the human IFN-β gene is essential for lipopolysaccharide-induced gene activation.
di: Goh, F, et al.
Pubblicazione: (2010)

Diverse mechanisms of IRF5 action in inflammatory responses
di: Khoyratty, T, et al.
Pubblicazione: (2018)

Diverse mechanisms of IRF5 action in inflammatory responses
di: Khoyratty, T, et al.
Pubblicazione: (2018)

TSG-6 Downregulates IFN-Alpha and TNF-Alpha Expression by Suppressing IRF7 Phosphorylation in Human Plasmacytoid Dendritic Cells
di: L. Kui, et al.
Pubblicazione: (2017-01-01)

IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling.
di: Helen M Lazear, et al.
Pubblicazione: (2013-01-01)

Advances and challenges in targeting IRF5, a key regulator of inflammation
di: Almuttaqi, H, et al.
Pubblicazione: (2018)

Defactinib inhibits PYK2 phosphorylation of IRF5 and reduces intestinal inflammation
di: Ryzhakov, G, et al.
Pubblicazione: (2021)

IL-17 stimulation results in a pro-inflammatory outcome during antiviral response in human cells
di: Ryzhakov, G, et al.
Pubblicazione: (2010)

Evolution of vertebrate immunity: sequence and functional analysis of the SEFIR domain family member Act1.
di: Ryzhakov, G, et al.
Pubblicazione: (2011)

M1 MACROPHAGES AND IRF5 EXACERBATE ATHEROSCLEROTIC DISEASE
di: Seneviratne, A, et al.
Pubblicazione: (2013)

IL-17 boosts proinflammatory outcome of antiviral response in human cells.
di: Ryzhakov, G, et al.
Pubblicazione: (2011)

iRhom2 is required for the secretion of mouse TNFα.
di: Siggs, O, et al.
Pubblicazione: (2012)

Cross-species analysis reveals evolving and conserved features of the nuclear factor κB (NF-κB) proteins.
di: Ryzhakov, G, et al.
Pubblicazione: (2013)

IL-17 receptor adaptor protein Act1/CIKS plays an evolutionarily conserved role in antiviral signaling.
di: Ryzhakov, G, et al.
Pubblicazione: (2012)

IL-17 receptor adaptor Act1/CIKS plays an evolutionarily conserved role in antiviral signalling
di: Ryzhakov, G, et al.
Pubblicazione: (2012)

Activation and Function of Interferon Regulatory Factor 5.
di: Ryzhakov, G, et al.
Pubblicazione: (2014)

The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection
di: Milton Pereira, et al.
Pubblicazione: (2024-02-01)

Intracellular IRF5 Dimerization Assay
di: Cherrie Sherman, et al.
Pubblicazione: (2021-05-01)

Physical and functional interaction among Irf8 enhancers during dendritic cell differentiation
di: Takaya Yamasaki, et al.
Pubblicazione: (2024-04-01)

Role of interferon regulatory factor 5 in regulation of the human tumor necrosis factor gene expression
di: Krausgrube, T, et al.
Pubblicazione: (2008)

IRF5 promotes influenza-induced inflammatory responses in human iPSC-derived myeloid cells and murine models
di: Forbester, JL, et al.
Pubblicazione: (2020)

DNA sequence polymorphism at the human tumor necrosis factor (TNF) locus. Numerous TNF/lymphotoxin alleles tagged by two closely linked microsatellites in the upstream region of the lymphotoxin (TNF-beta) gene.
di: Nedospasov, SA, et al.
Pubblicazione: (1991)

IRF5 guides monocytes toward an inflammatory CD11c+ macrophage phenotype and promotes intestinal inflammation
di: Corbin, AL, et al.
Pubblicazione: (2020)

An STS in the human TNF locus located at 6p21.3.
di: Udalova, I, et al.
Pubblicazione: (1991)

Anti-TNF therapy
di: Udalova, I, et al.
Pubblicazione: (2016)

Interaction of AP-1 with a cluster of NF-kappa B binding elements in the human TNF promoter region.
di: Udalova, I, et al.
Pubblicazione: (2001)